Immune Function Of Blood Cells 9/27 Flashcards
What do common lymphoid progenitors differentiate into?
B cells, T cells, and NK cells
How do eosinophils kill heminthic parasites?
Humoral immunity coats helminthic with IgE, which binds to FcRI receptor on eosinophils.
Eosinophils release granulocytes and toxic mediators.
IL-5 secreted by Th2 promotes eosinophil response to parasites.
What cytokines to basophils secrete and which immunoglobulin do they promote?
Cytokines: IL-4 & IL-13
Promote IgE synthesis
What is the function of myeloid dendritic cells?
Phagocytize microbes, chop them into small components, produce cytokines that 1. Initiate inflammation and 2. Stimulate adaptive immune responses
What is the function of plasmacytoid dendritic cells?
detect viral infection using TLR-7 and TLR-9
Produce IFN
Secrete INTERFERON
What stimulates NK cells and what do they secrete?
NK cells are stimulated by IL-12 prod by macrophages and secrete IFN-y
IFN-y activates macrophages to kill phagocytized microbes.
What is the function of B lymphocytes?
Recognition of antigens through cell surface receptors (antibodies)
What do B lymphocytes mature into?
PLASMA CELLS: remain fixed in tissues and secrete soluble antibody
What do helper T CD4 lymphocytes do?
Recognize antigens on APCs and secrete cytokines, which activate macrophages, inflammation, and other T and B lymphocytes
What to cytotoxic CD8 T lymphocytes do?
Recognize antigens infected w virus and kill them.
**In contrast, NK cells detect cell stress, not antigens as cd8 cells do
What do platelets do?
Release inflammatory mediators:
- fibrinogen
- plasminogen
- lipids
- serotonin
What is the immune function of red blood cells?
Express CR1 for activated C3.
After binding, RBCs circulate through liver and spleen. RBCs transfer immune complexes to macrophages for phagocytosis.
