Immune Deficiency in a clinical setting

Question 1

What are lymphocyte surface markers?

Answer 1

Can measure the different type of lymphocytes in blood using different markers on surface of cell

Question 2

what are the lymphocyte surface markers on t cells?

Answer 2

CD3/CD4

CD3/CD8

Question 3

What are the lymophocyte markers on the B cells?

Answer 3

CD19

Question 4

What are the lymphocyte markers on the NK cells?

Answer 4

CD16/56

Question 5

What is the role of antibodies?

Answer 5

To help fight the infection
Neutralise the antigen
Activate phagocytes
activate complement cascade

Question 6

Where do antibody deficiency infections usually occur?

Answer 6

resp tract

Question 7

What happens with the complement system?

Answer 7

Promotes inflammation
activates phagocytes
killing of pathogens
assists with removing foreign/tissue damage

Question 8

How is immune deficiency treated?

Answer 8

Antimicrobial prophylaxis
immunoglobulin replacement therapy
bone marrow transplant
gene therapy