images V Flashcards

1
Q
A

cortical degeneration of AD

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2
Q
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AD

plaques with dystrophic neurties surrounding amyloid cores

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3
Q
A

AD

plaque core and surrounding neutropil are immunoreactive for alpha-beta

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4
Q
A

AD

extracellular tangles

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5
Q
A

AD

Neurofibrillary Tangles

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6
Q
A

AD

Neurofibrillary Tangles

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7
Q
A

AD

Neurofibrillary Tangles

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8
Q
A

Tau IHC

tangle on left

plaque on right

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9
Q
A

CEREBRAL AMYLOID ANGIOPATHY

always seen in AD, but not AD

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10
Q
A

Cerebral amyloid angiopathy. Beta amyloid immunostain

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11
Q
A

Frontotemporal Lobar Degenerations (FTLD)

the smooth circular inclusions are picks bodies and specific to picks disease

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12
Q
A

Frontotemporal Lobar Degenerations (FTLD)

Tau deposition

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13
Q
A

picks bodies (aggregates of Tau)

picks disease- subtype of Frontotemporal Lobar Degenerations (FTLD)

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14
Q
A

Depigmentation of the substantia nigra in PD (left). Normal sustantia nigra (right). The black color comes from melanin in catecholaminergic cells

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15
Q
A

Normal sustantia nigra-zona compacta. Melanin in neuronal body

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16
Q
A

gliosis d/t Loss of sustantia nigra neurons in PD.

17
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A

Lewy body in a SN neuron. The melanin granules are red-brown.

18
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A

Multiple system atrophy (MSA). A, Severe atrophy of the basis pontis is evidence in a case of MSA-C.

19
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A

Multiple system atrophy

B, Inclusions in oligodendrocytes contain α-synuclein.

20
Q
A

multiple system atrophy

Atrophy of the putamen, which may have a steele -gray color. WHITE MATTER degeneration

21
Q
A

multiple system atrophy

Atrophy of the basis pontis.

22
Q
A

HD

loss of putamen and caudate

23
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A

HD

The inclusions consist of aggregated abnormal huntingtin protein (combined with ubiquitin)

24
Q
A

HD. Atrophy of the caudate nuclei and dilatation of the lateral ventricles

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caudate nucleus: HD on left and normal on right GFAP stain shows astrocyte proliferation in HD
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Friedreich's ataxia. Spinal cord, myelin stain. Degeneration of the posterior columns, spinocerebellar, corticospinal, and other tracts. Notice atrophy of dorsal roots.
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PML. Demyelination of the cerebellum and pons.
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PML. Enlarged homogeneous oligodendrocyte nucleus with inclusion.
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MS ## Footnote Peri -ventricular white matter lesions are common.
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Demyelination of the spinal cord. The pale lesions are plaques. The deep blue areas are normal myelin.
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Multiple sclerosis (MS). Unstained regions of demyelination (MS plaques) around the fourth ventricle
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MS normal tissue on left with plaque on right
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CENTRAL PONTINE MYELINOLYSIS (CPM) d/t rapid correction of hyponatremia
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