images V

Question 1

Answer 1

cortical degeneration of AD

Question 2

Answer 2

AD

plaques with dystrophic neurties surrounding amyloid cores

Question 3

Answer 3

AD

plaque core and surrounding neutropil are immunoreactive for alpha-beta

Question 4

Answer 4

AD

extracellular tangles

Question 5

Answer 5

AD

Neurofibrillary Tangles

Question 6

Answer 6

AD

Neurofibrillary Tangles

Question 7

Answer 7

AD

Neurofibrillary Tangles

Question 8

Answer 8

Tau IHC

tangle on left

plaque on right

Question 9

Answer 9

CEREBRAL AMYLOID ANGIOPATHY

always seen in AD, but not AD

Question 10

Answer 10

Cerebral amyloid angiopathy. Beta amyloid immunostain

Question 11

Answer 11

Frontotemporal Lobar Degenerations (FTLD)

the smooth circular inclusions are picks bodies and specific to picks disease

Question 12

Answer 12

Frontotemporal Lobar Degenerations (FTLD)

Tau deposition

Question 13

Answer 13

picks bodies (aggregates of Tau)

picks disease- subtype of Frontotemporal Lobar Degenerations (FTLD)

Question 14

Answer 14

Depigmentation of the substantia nigra in PD (left). Normal sustantia nigra (right). The black color comes from melanin in catecholaminergic cells

Question 15

Answer 15

Normal sustantia nigra-zona compacta. Melanin in neuronal body

Question 16

Answer 16

gliosis d/t Loss of sustantia nigra neurons in PD.

Question 17

Answer 17

Lewy body in a SN neuron. The melanin granules are red-brown.

Question 18

Answer 18

Multiple system atrophy (MSA). A, Severe atrophy of the basis pontis is evidence in a case of MSA-C.

Question 19

Answer 19

Multiple system atrophy

B, Inclusions in oligodendrocytes contain α-synuclein.

Question 20

Answer 20

multiple system atrophy

Atrophy of the putamen, which may have a steele -gray color. WHITE MATTER degeneration

Question 21

Answer 21

multiple system atrophy

Atrophy of the basis pontis.

Question 22

Answer 22

HD

loss of putamen and caudate

Question 23

Answer 23

HD

The inclusions consist of aggregated abnormal huntingtin protein (combined with ubiquitin)

Question 24

Answer 24

HD. Atrophy of the caudate nuclei and dilatation of the lateral ventricles

Question 25

Answer 25

caudate nucleus: HD on left and normal on right

GFAP stain shows astrocyte proliferation in HD

Question 26

Answer 26

Friedreich’s ataxia.

Spinal cord, myelin stain.

Degeneration of the posterior columns, spinocerebellar, corticospinal, and other tracts.

Notice atrophy of dorsal roots.

Question 27

Answer 27

PML. Demyelination of the cerebellum and pons.

Question 28

Answer 28

PML. Enlarged homogeneous oligodendrocyte nucleus with inclusion.

Question 29

Answer 29

MS

Peri -ventricular white matter lesions are common.

Question 30

Answer 30

Demyelination of the spinal cord.

The pale lesions are plaques.

The deep blue areas are normal myelin.

Question 31

Answer 31

Multiple sclerosis (MS).

Unstained regions of demyelination (MS plaques) around the fourth ventricle

Question 32

Answer 32

MS

normal tissue on left with plaque on right

Question 33

Answer 33

CENTRAL PONTINE MYELINOLYSIS (CPM)

d/t rapid correction of hyponatremia