images V Flashcards

cortical degeneration of AD

AD
plaques with dystrophic neurties surrounding amyloid cores

AD
plaque core and surrounding neutropil are immunoreactive for alpha-beta

AD
extracellular tangles

AD
Neurofibrillary Tangles

AD
Neurofibrillary Tangles

AD
Neurofibrillary Tangles

Tau IHC
tangle on left
plaque on right

CEREBRAL AMYLOID ANGIOPATHY
always seen in AD, but not AD

Cerebral amyloid angiopathy. Beta amyloid immunostain

Frontotemporal Lobar Degenerations (FTLD)
the smooth circular inclusions are picks bodies and specific to picks disease

Frontotemporal Lobar Degenerations (FTLD)
Tau deposition

picks bodies (aggregates of Tau)
picks disease- subtype of Frontotemporal Lobar Degenerations (FTLD)

Depigmentation of the substantia nigra in PD (left). Normal sustantia nigra (right). The black color comes from melanin in catecholaminergic cells

Normal sustantia nigra-zona compacta. Melanin in neuronal body

gliosis d/t Loss of sustantia nigra neurons in PD.

Lewy body in a SN neuron. The melanin granules are red-brown.

Multiple system atrophy (MSA). A, Severe atrophy of the basis pontis is evidence in a case of MSA-C.

Multiple system atrophy
B, Inclusions in oligodendrocytes contain α-synuclein.

multiple system atrophy
Atrophy of the putamen, which may have a steele -gray color. WHITE MATTER degeneration

multiple system atrophy
Atrophy of the basis pontis.

HD
loss of putamen and caudate

HD
The inclusions consist of aggregated abnormal huntingtin protein (combined with ubiquitin)

HD. Atrophy of the caudate nuclei and dilatation of the lateral ventricles








