IHD

Question 1

Name 2 types of Angina

Answer 1

Classical - Atherosclerotic
Prinz metal - Vasospasm

Question 2

DOC Prinz metal angina

Answer 2

CCBs - dipins - vasdilation

Question 3

How do nitrates work?

Answer 3

Indirect NO donor which increase guanyl cyclase which increase C-GMP which act as VD

Question 4

Nitrates are more ___________

Answer 4

Veno dilators
Decrease end diastolic volume = decrease preload

Question 5

How do beta-blockers help in angina?

Answer 5

decrease HR, workload and oxygen demand

Question 6

Why don’t we give beta-blockers in Prinz metal angina?

Answer 6

Risk of VC

Question 7

Action of CCBs and KCOs in angina?

Answer 7

VD = decrease after load

Question 8

Name a KCO

Answer 8

Nicorandil

Question 9

Anti-angina drug that causes inverse robin hood/coronary steal phenomena?

Answer 9

Dipyridamole - NOT GOOD

Question 10

Enzyme used for Clopidogrel metabolism?

Answer 10

CYP2C19 - inhibited by Omeprazole PPI

Question 11

_________ is irreversible COX inhibitor.

Answer 11

Aspirin
hence longer action

Question 12

How long before surgery we should stop aspirin?

Answer 12

1 week before
T1/2 - 4 hours

Question 13

Heparin anti-dote

Answer 13

Protamine sulfate

Question 14

TOC STEMI

Answer 14

PCI
DTB - less than 90 min

Question 15

Anticoagulant used in PCI

Answer 15

LMW - overall best