Antiarrhythmic drugs

Question 1

Number and name of Antiarrhythmic drugs?

Answer 1

4 classes
SBPCA
1. Sodium blocker
2. Beta blocker
3. Potassium blocker
4. Ca blocker

Question 2

Which drugs cause QT widening?

Answer 2

Class 1(a) - Na + Pot blockers
Procainamide
Quinidine
Disopyramide - anticholinergic SE dry mouth

Question 3

Which class of Antiarrhythmic drugs cause Hypoglycemia?

Answer 3

Class 1(a)

Question 4

Which class 1 Antiarrhythmic drug causes SLE?

Answer 4

Procainamide

Question 5

Which anti-malarial drug is Antiarrhythmic?

Answer 5

Quinidine - given with dextrose because high risk of hypoglycemia

Question 6

Which Antiarrhythmic drugs cause wide QRS?

Answer 6

Class 1 Na blocker

Question 7

Name class 1(b) K opener drugs

Answer 7

Lignocaine - LA used in arrhythmia
Phenytoin - antiepileptic used in arrhythmia
Tocainide - suppression of bone marrow

Question 8

DOC MI + Digoxin toxicity?

Answer 8

Lignocaine

Question 9

DOC VT + MI?

Answer 9

Lignocaine

Question 10

Name Class 1 antiarrhythmic drugs which have no effect on K?

Answer 10

Class 1(c)
Encainide
Flecainide

Question 11

Class 1(c) antiarrhythmic drug used in WPW and resistant VT?

Answer 11

Flecainide

Question 12

Rate controlling DOC Atrial fibrillation/atrial flutter

Answer 12

Beta blockers

Question 13

Which beta blockers have additional Na blocking properties?

Answer 13

Propranolol, Metoprolol

Question 14

Class 2 antiarrhythmic drug used in EMERGENCY

Answer 14

Esmolol

Question 15

Class 2 antiarrhythmic drug not used in Asthma

Answer 15

Propranolol - causes bronchoconstriction

Question 16

What are Class 2 antiarrhythmic drugs?

Answer 16

Beta blockers
decrease rate and contractility

Question 17

Name a medical/chemical defibrillator drug

Answer 17

Bretylium - class 3 antiarrhythmic drug

Question 18

Class 1 and class 3 antiarrhythmic drugs cause?

Answer 18

Wide QRS

Question 19

MOA Bretylium

Answer 19

Decrease release of catecholamines so decrease BP (MC SE)

Question 20

Which antiarrhythmic drug causes blue man syndrome?

Answer 20

Amiodarone
ab tak chappan - loading dose given, looooong half life 3-8 weeks

Question 21

SE of Amiodarone

Answer 21

Skin- blue man syndrome
Eyes- corneal/lenticular opacities
Thyroid- both increase and decrease release
Lung fibrosis- type 2 pneumocytes
Myocarditis
Liver damage

Question 22

Which antiarrhythmic drug has broad spectrum of action?

Answer 22

Amiodarone Class 3
blocks all Na, K and beta channels
used in both VT and SVT

Question 23

Class 3 antiarrhythmic drugs used for AF

Answer 23

Dofetilide
Ibutilide more commonly

Question 24

Name a antiarrhythmic drug which is both class 2 and 3

Answer 24

Sotalol

Question 25

Class 4 antiarrhythmic drug used to control rate in SVT

Answer 25

Verapamil - strong effect

Question 26

Which class 4 drugs are not safe with beta blockers?

Answer 26

Verapamil and Diltiazem (decrease HR) Non-DHP drugs

Question 27

Which class 4 drug is safe with beta blockers?

Answer 27

DHPs - dipins but they cause reflex tachycardia

Question 28

DOC torsades de pointes

Answer 28

Mg

Question 29

Use of class 5 misc Digitalis drugs in arrhythmia

Answer 29

SVT in CHF

Question 30

Mg uses in arrhythmia

Answer 30

Attack + prophylaxis (given with Propranolol)

Question 31

Which class 5 antiarrhythmic is not safe in asthma?

Answer 31

Adenosine - bronchoconstriction Blocks Na in hyperpolarized state

Question 32

How is Adenosine given?

Answer 32

IV with 50 ml NS to push to heart

Question 33

DOC Brady-arrythmias

Answer 33

Atropine - doesn't work in transplanted heart

Question 34

DOC sinus bradycardia, 1' heart block and Mobitz type 1

Answer 34

Atropine

Question 35

TOC Mobitz type 2 and complete heart block

Answer 35

Pacemaker

Question 36

Topical use of Mg salt

Answer 36

Hygroscopic effect, decrease edema and cellulitis

Question 37

Oral use of Mg salt

Answer 37

Constipation and Antacids

Question 38

Why is Mg salt used as nebulizer?

Answer 38

Bronchodilator - asthma attack

Question 39

First sign of Mg toxicity

Answer 39

DTR loss

Question 40

Mg salt injection use?

Answer 40

Anti-convulsant and Tocolytic = used in eclampsia Anti-arrhythmic