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My own Pharma > Antiarrhythmic drugs > Flashcards

Antiarrhythmic drugs Flashcards

1
Q

Number and name of Antiarrhythmic drugs?

A

4 classes
SBPCA
1. Sodium blocker
2. Beta blocker
3. Potassium blocker
4. Ca blocker

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2
Q

Which drugs cause QT widening?

A

Class 1(a) - Na + Pot blockers
Procainamide
Quinidine
Disopyramide - anticholinergic SE dry mouth

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3
Q

Which class of Antiarrhythmic drugs cause Hypoglycemia?

A

Class 1(a)

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4
Q

Which class 1 Antiarrhythmic drug causes SLE?

A

Procainamide

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5
Q

Which anti-malarial drug is Antiarrhythmic?

A

Quinidine - given with dextrose because high risk of hypoglycemia

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6
Q

Which Antiarrhythmic drugs cause wide QRS?

A

Class 1 Na blocker

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7
Q

Name class 1(b) K opener drugs

A

Lignocaine - LA used in arrhythmia
Phenytoin - antiepileptic used in arrhythmia
Tocainide - suppression of bone marrow

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8
Q

DOC MI + Digoxin toxicity?

A

Lignocaine

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9
Q

DOC VT + MI?

A

Lignocaine

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10
Q

Name Class 1 antiarrhythmic drugs which have no effect on K?

A

Class 1(c)
Encainide
Flecainide

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11
Q

Class 1(c) antiarrhythmic drug used in WPW and resistant VT?

A

Flecainide

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12
Q

Rate controlling DOC Atrial fibrillation/atrial flutter

A

Beta blockers

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13
Q

Which beta blockers have additional Na blocking properties?

A

Propranolol, Metoprolol

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14
Q

Class 2 antiarrhythmic drug used in EMERGENCY

A

Esmolol

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15
Q

Class 2 antiarrhythmic drug not used in Asthma

A

Propranolol - causes bronchoconstriction

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16
Q

What are Class 2 antiarrhythmic drugs?

A

Beta blockers
decrease rate and contractility

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17
Q

Name a medical/chemical defibrillator drug

A

Bretylium - class 3 antiarrhythmic drug

18
Q

Class 1 and class 3 antiarrhythmic drugs cause?

19
Q

MOA Bretylium

A

Decrease release of catecholamines so decrease BP (MC SE)

20
Q

Which antiarrhythmic drug causes blue man syndrome?

A

Amiodarone
ab tak chappan - loading dose given, looooong half life 3-8 weeks

21
Q

SE of Amiodarone

A

Skin- blue man syndrome
Eyes- corneal/lenticular opacities
Thyroid- both increase and decrease release
Lung fibrosis- type 2 pneumocytes
Myocarditis
Liver damage

22
Q

Which antiarrhythmic drug has broad spectrum of action?

A

Amiodarone Class 3
blocks all Na, K and beta channels
used in both VT and SVT

23
Q

Class 3 antiarrhythmic drugs used for AF

A

Dofetilide
Ibutilide more commonly

24
Q

Name a antiarrhythmic drug which is both class 2 and 3

25
Q

Class 4 antiarrhythmic drug used to control rate in SVT

A

Verapamil - strong effect

26
Q

Which class 4 drugs are not safe with beta blockers?

A

Verapamil and Diltiazem (decrease HR)
Non-DHP drugs

27
Q

Which class 4 drug is safe with beta blockers?

A

DHPs - dipins
but they cause reflex tachycardia

28
Q

DOC torsades de pointes

29
Q

Use of class 5 misc Digitalis drugs in arrhythmia

A

SVT in CHF

30
Q

Mg uses in arrhythmia

A

Attack + prophylaxis (given with Propranolol)

31
Q

Which class 5 antiarrhythmic is not safe in asthma?

A

Adenosine - bronchoconstriction
Blocks Na in hyperpolarized state

32
Q

How is Adenosine given?

A

IV with 50 ml NS to push to heart

33
Q

DOC Brady-arrythmias

A

Atropine - doesn’t work in transplanted heart

34
Q

DOC sinus bradycardia, 1’ heart block and Mobitz type 1

35
Q

TOC Mobitz type 2 and complete heart block

36
Q

Topical use of Mg salt

A

Hygroscopic effect, decrease edema and cellulitis

37
Q

Oral use of Mg salt

A

Constipation and Antacids

38
Q

Why is Mg salt used as nebulizer?

A

Bronchodilator - asthma attack

39
Q

First sign of Mg toxicity

40
Q

Mg salt injection use?

A

Anti-convulsant and Tocolytic = used in eclampsia
Anti-arrhythmic

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