idiopathic inflammatory myelitis

Question 1

Define idiopathic inflammatory myelitis

Answer 1

idiopathic inflammatory myocitis-infiltration of the proximal muscle by cells

deramtomyosistis-skin +mucle

Polymyosistis-only muscle

Question 2

Signs and Sx of idiopathic inflammatory myelitis

Answer 2

Dermatomyositis-Heliotrope rash-purple rounder the eyes-upper eyelids
Gottrons papuples-erythrema over knuckles
shawl sign-looks like sunburn in shawl patter
Mechanics hands-

reynauds
Difficulties moving/doing mechanical moves
muscle weakness and atrophy

fatigue, weight loss

Question 3

Investigations of idiopathic inflammatory myelitis

Answer 3

Look at muscle
CK-super raised (few thousands)
ANA-sometimes hit or miss

MRI scan-can see oedema in muscle
EMG-abnormal function

confirm with muscle biopsy

Question 4

Management of idiopathic inflammatory myelitis

Answer 4

acute flares- steroids +/- IVIG
Ongoing- oral steroids 1st line
azathioprine/methotrexate 2nd

+ always do a malignancy screen as often caused by cancers

Question 5

Aetiology and risk factor of idiopathic inflammatory myelitis

Answer 5

Aetiology is unknown
But thought to be genetic, environment, and causative factors (EBV)
OFEN LINKED WITH CANCERS

risk factors:

Children and under 40
FHX
Black Female
White male
exposure to sun

Question 6

Epidiemology of idiopathic inflammatory myelitis

Answer 6

rare -5.5 in 1 million in US