ID: Quinolones, Urinary Antiseptics, and Anti-mycobacterial agents Flashcards
*Ending for fluoroquinolines
-floxacin or -oxacin
*first gen quinolone? And its spectrum
- nalidixic acid
- narrow spectrum for gram-
*what was the quinolone class modified to? Spectrum? Resistance? Kinetics?
- fluoroquinolones
- larger spectrum vs quinolones
- more effective against resistance vs quinolones
- improved kinetics vs quinolones
*Pros to Floroquinolones (4)
- highly effective
- broad spectrum
- high PO bioavailability
- large volume of distribution
*cons to floroquinolones (3)
- widespread use had lead to resistance
- serious adv eff can occu
- multiple drug-drug interactions
*generally when do we use fluoroquinolones?
-when benefits outweight the risk
- list the second gen Fluoros + routes
* spectrum
- Ciprofloxacin—PO, IV, ophthalmic, otic
- Ofloxacin—PO, ophthalmic, otic
Spectrum:
- increased acitivty
- aerobic gram- bacteria **
- *cipro has weak coverage aganst strep pneumoniae
Ofloxacin: enhanced coverage of staph and strep
- List the third gen fluoros + routes
- spectrums
-levofloxacin—PO, IV
Spectrum:
-same as second gen
+
better gram+ coverage and atypical organisms
*list the fourth gen Fluoros + routes
- Gatifloxacin—ophthalmic
- Delafloxacin—PO, IV
- Moxifloxacin—PO, IV, ophthalmic
*two enzymes that fluoros target?
- DNA gyrase: found in gram-
- Topoisomerase IV inhibition: in gram+
*action of fluoros on bacteria— bacteriostatic or cidal
-cidal bcause it causes cell death
*MOA fluoros
-targets two enzymes: DNA Gyrase and Topoisomerase IV inhibition
DNA gyrase—removes excess positive supercoiling in the DNA helix (gram-)
T. IV Inhib—affects separation of interlinked daughter DNA molecules (gram+)
*Spectrum for fluoros:
- aeriobic gram +
- aerobic gram-
- atypical: chlamydia, Legionelle, Mycoplasma
- anaerobes
*should fluoros be used for tx of uncomplicated infecetions? Why?
- NO
- due to adverse effects—also when alternative agents with lower toxicity profiles are available
- in 2016 FDA recommended this
*ex of uncomplicated infections that should not be tx with fluoros
- acute rhinositis
- uncomplicated cystitis
- acute bronchitis
which is the best fluoro for aerobic, gram-, pseudomonas
- UTI
- Pyelonephritis
- gastroenteritis
- otitis
- eye infections
Ciprofloxacin
Spectrum for Ciprofloxacin
aerobic gram-
Pseudomonas
*not much gram+ coverage
indications for Cirpofloxacin
UTI Pyelonephritis gastroenteritis Otitis--drops eye infections
***much better for gram- vs gram+
which has better gram + coverage:
-Ciprofloxacin or Levo/Moxifloxacin
Levo and moxi
spectrum and indications for Levofloxacin
spectrum:
* *more gram + coverage vs cipro
* gram-
* gram+
* anaerobes
* mycobacterium
* respiratory infections: strep, hamepholius, and moraxella
- 2nd DOC for mycobacterium TB
- UTI
- Pyelonephritis
- pneumoina