GYN/Final: Random facts/grouping

Question 1

Good CNS penetration

Answer 1

• fluconazole
• Voriconazole
• 5-FC
• Melosoprol

Question 2

what drug to you avoid in patients with left ventricular dysfunction

Answer 2

Itraconazole

Question 3

CYP inhibitors

Answer 3

Technically all AZOLES are a CYP450 inhibitors–to varying degrees

• Voriconazole ***
• Terbinafine

Caspofungin

Question 4

which drug has a non-linear pharmacokinetics?

Answer 4

Voriconazole

**increase the dose by 50%=can lead to 150% increase in [serum]

Question 5

List the Imidazoles

Answer 5

Clotrimazole
Miconazole
Efinaconazole

Question 6

List the Triazoles

Answer 6

Fluconazole
Itraconazole
Voriconazole

Question 7

which medication has a 48 week tx duration

Answer 7

Efinaconazole

Question 8

list the azoles with good CNS penetration and the ones with bad

Answer 8

GOOD:

• Fluconazole
• Isavuconazole
• Voriconazole

BAD:
*Itraconazole

Question 9

advantages to Echnocandins (2)

Answer 9

1. good activity against fluconazole resistant Candida Glabrata and C. Krusei
2. Low hepatic or renal toxicity

Question 10

high fat meals increases abs of what drugs

Answer 10

Griseofluvin

Protease Inhibitors

Question 11

CYP450 inducer

Answer 11

Griseofluvin

Question 12

what drug causes metallic taste as a SE

Answer 12

Metronidazole

Question 13

disulfiram-like reaction

Answer 13

metronidazole

Question 14

drug causing QTc&raquo_space;»

Answer 14

1. chloroquine
2. Artemisinins in high doses
3. Pentamidine causes cardiac arrhythmias
4. Voriconazole (IV, PO)
5. Metronidazole

Question 15

before initiating what drug would you test a patient for G6PD? and why

Answer 15

• ***Primaquine
• Melarsoprol

can cause hemolytic anemia in these PT

Question 16

anti-malarial drugs OK for pregnancy

Answer 16

Mefloquine

Question 17

which drug requires an eye exam during extended use?

Answer 17

Chloroquine

Question 18

what drug comes from the bark of cinchona tree

Answer 18

Quinine

Question 19

which drug requries plasma glucose monitoring during tx?

Answer 19

Pentamidine–causes life threatening hyPOglycemia

Question 20

what drugs need renal dosing

Answer 20

1. Acyclovir
2. Entecavir
3. Cidofovir–start low and work up

Question 21

drugs that will interact with CYP450 inhibs/inducers

Answer 21

Warfarin **
Phenytoin*
BBs
CCBs