GYN/Final: Random facts/grouping Flashcards
Good CNS penetration
- fluconazole
- Voriconazole
- 5-FC
- Melosoprol
what drug to you avoid in patients with left ventricular dysfunction
Itraconazole
CYP inhibitors
Technically all AZOLES are a CYP450 inhibitors–to varying degrees
- Voriconazole ***
- Terbinafine
Caspofungin
which drug has a non-linear pharmacokinetics?
Voriconazole
**increase the dose by 50%=can lead to 150% increase in [serum]
List the Imidazoles
Clotrimazole
Miconazole
Efinaconazole
List the Triazoles
Fluconazole
Itraconazole
Voriconazole
which medication has a 48 week tx duration
Efinaconazole
list the azoles with good CNS penetration and the ones with bad
GOOD:
- Fluconazole
- Isavuconazole
- Voriconazole
BAD:
*Itraconazole
advantages to Echnocandins (2)
- good activity against fluconazole resistant Candida Glabrata and C. Krusei
- Low hepatic or renal toxicity
high fat meals increases abs of what drugs
Griseofluvin
Protease Inhibitors
CYP450 inducer
Griseofluvin
what drug causes metallic taste as a SE
Metronidazole
disulfiram-like reaction
metronidazole
drug causing QTc»_space;»
- chloroquine
- Artemisinins in high doses
- Pentamidine causes cardiac arrhythmias
- Voriconazole (IV, PO)
- Metronidazole
before initiating what drug would you test a patient for G6PD? and why
- ***Primaquine
- Melarsoprol
can cause hemolytic anemia in these PT
anti-malarial drugs OK for pregnancy
Mefloquine
which drug requires an eye exam during extended use?
Chloroquine
what drug comes from the bark of cinchona tree
Quinine
which drug requries plasma glucose monitoring during tx?
Pentamidine–causes life threatening hyPOglycemia
what drugs need renal dosing
- Acyclovir
- Entecavir
- Cidofovir–start low and work up
drugs that will interact with CYP450 inhibs/inducers
Warfarin **
Phenytoin*
BBs
CCBs
