ID Medical Mycology II - Dimorphic Fungi Flashcards
Dark, moist habitat
Moderate temperature
Do not attack mammals (CMI)
Fungi
- Restricted habitat
- Convert to yeast to survive at higher temperatures (thermal dimorphism)
- May infect normal and IC hosts
- Most commonly a granulomatous response
Dimorphic fungi
Dimorphic Fungi- Often more clinical disease in _____
males
Mississippi and Ohio River basins
Also Africa/ India
Blastomyces dermatitidis
Is blasto usually symptomatic
not usually
can go to lungs (fever/cough)
disseminates to skin/bone
Blasto buzz words
Pyogranulomatous response
Broad-based budding yeast
We thought it was Coccidioides immitis, we saw it in AZ and NM, but now we call this new thing
Coccidioides posadasii
disease: Pulmonary coccidioidomycosis
Coccidioidomycosis usually present with ?
erythema nodosum
Coccidioidomycosis disiminates to
bone and skin
Coccidioidomycosis makes what form in body
Spherules
can be full of spores
Coccidioidomycosis buzzwords
Diagnostic forms
Spherules
Alternating arthroconidia
confirmed by positive DNA probe
Highest in Mississippi-Ohio River Valley region
Blastomycosis
B. dermatidis
Any detectable antibody for coccidioides is what?
Active disease
Histoplasmosis
Disease
–Primary pulmonary infection: mild flu-like; may have erythema nodosum
–Chronic pulmonary infection: chronic calcified nodules (looks like TB on CXR)
–Disseminated: rare, usu immunocompromised: oropharyngeal ulcers (tongue), bone, liver, spleen and adrenals
Soil saprophyte found in dry, sandy, and alkaline soils associated with hot summers and mild winters
Coccidioidomycosis
Coccidioides immitis