ID Flashcards
Is HIV screening recommended for all pt 15-65 regardless of risk factors?
yep, with HIV p24 Ag and Ab testing
HA, confusion, breathing symptoms, diarrhea + hyponatremia and elevated LFTs
legionella
Legionella tx
macrolide or fluorgoquinolone
UTI with alkaline urine and struvite stone
proteus infection
Undercooked meat + foreign travel + GI complaints followed by periorbital edema, edema, myositis, eosinophilia + roundworm parasite
Trichinellosis
Fever, abdominal pain, salmon-colored rash, hepatosplenomegaly
Typhoid fever
camping, diarrhea, flatulence, abdominal cramps, weight loss, nausea
giardia
fever, HA, retro-orbital pain, rash, significant myalgia and arthralgias
Dengue fever
Risk factors for bacillary angiomatosis
cat exposure, homelessness, CD4 <100
How does bacillary angiomatosis manifest
Skin
Systemic - fever, night sweats, fatigue
Organs - liver, bone, CNS
Bacillary angiomatosis treatment
Doxy or erythromycin + INCREASE CD4 with ART
Locations of nocardia infection
lung + brain
interstital pneumonia when CD4 < 200
Pneumocysits jiroveccin
colorectal disease + IE
s gallolyticus, s bovis
tx of mucormycosis (nasal infection + poorly managed DM)
surgical debridement plus amphotericin B `
+ RF, elevated ESR, normocytic anemia + constitutional sx + dyspnea, cough, edema, osler nodes + septic embolic to brain, spleen, lung + glomerulonephritis
variety of IE symptoms given its potential to transform into acute, subacute, chronic manifestations
Adult Still disease
inflammatory disorder - recurrent high fevers, arthritis/arthralgias, salmon-colored rash, + ESR
Patient presents with indolent course of cough, fever, dyspnea and has XR suspicious for PCP which is confirmed with BAL. What treatment to start?
TMP-SMX and steroids, also test for HIV and start ART if appropriate
Tx for CAP
Ceftriaxone + azithromycin
Tx for HAP
Vancomycin + piperacillin-tazobactam
Travelers’ diarrhea that is prolonged, profuse, water
cryptosporidium parvum, cyclospora, giardia
Diarrhea quality with entamoeba histolytic and shigella
dysentary - bloody and mucoid
HIV +, subacute fever, HA, increased ICP sx
cryptococcal meningitis
cognitive and personality changes, focal neuro deficitys, seizures, temporal lobe involvement
HS encepahlitis
MRI with patchy areas of white matter, HIV, JC virus
progressive multifocal leukoencephalopathy (PML)
fever, back pain, focal spinal tenderness
osteomyelitis - get blood cx, inflammatory markers, MRI then CT guided bone biopsy
List two main opportunistic infections and the ppx tx
Pneumocystis pneumonia - TMP-SMX
CMV - ganciclovir or valganciclovir
great lakes, pulmonary illnes, verrucuous nodules and plaques
blastomycosis
When and how ppx against pneumocystic jirovecci
CD4 < 200 + TMP-SMX
When and how ppx against toxoplasma gondii
CD4 < 100 + TMP-SMX
When and how ppx against MAC
CD4 < 50 + Azithromycin
When and how ppx against Histoplasma capsulatum
CD4 < 150 + Itraconazole
Which HIV OI require TMP-SMX tx and when
Pneumocystis ( < 200) and Toxo ( < 100)
You ppx against this OI with Azithromycin when CD4 < 50
MAC
pulmonary disease in immunocompromised host + nodular, cavitary lesions in upper lobes + sputum with filamentous, gram positive, weakly acid-fast rods
Nocardia, tx with TMP-SMX
pulmonay disease + acid-fast negative hyphae
Aspergillus
Tx of penicillin sensitive IE
IV abx like ceftriaxone for 4 weeks
Recent immigtation, abdominal pain, fever, leukocytosis, liver abscess preceded by bloody diarrhea
amebic abscess by entamoeba histolytica - treat with metronidazole
Tx of hydatid liver cyst due to echinococcus
aspiration + albendazole
are pt with HIV at increased risk of CAP with s pneumo
yep
recent flu with acute worsening with high fever, productive cough, hemoptysis, leukopenia and found to have multilobar cavitary lesions on XR
post viral s aureus pneumonia
immunocompromised + fever, pleuritic CP, hemoptysis
Aspergillus
high fever and GI sx prior to pulmonary sx
LEgionella, will see hyponatremia
rapid onset fever, myalgias, nuchal rigidity, petechial rash, shock, CSF with low glucose and high protein
Meningococcal meningitis, treat with ceftriaxone + vancomycin
Hiv + HA, confusion, focal deficits, fever + MRI with ring-enhancing lesions
Toxo, should be on ppx if CD4 < 100, TMP-SMX
bug in epididymitis of old man
e coli
3 bacteria that can cause bloody diarrhea
e coli, shigella, campylobacter
duration of tick attachment o ppx for Lyme
36 hrs, remove with tweezers
ppx vs treatment of Toxo
ppx = TMP-SMX, tx = sulfadiazine and pyrimethamine
CD4 < 100 with HA, fever, focal neuro deficits, AMS
Toxo, tx with Sulfadiazine and Pyrimethamine
MRI findings of Toxo
ring enhancing lesion
MRI findings of CMV
multifocal micronodules or ventricular enhancement
immunocompromised + lung or brain + filamentous, aerobic, gram-positive, partially acid fast
nocardia, tx with TMP-SMX
NE united states + flu-like symptoms + anemia, thrombocytopenia + blood smear with Maltese cross
Babesiosis - ixodes scapularis
Two treatments for babesiosus
Atovaquone + azithromycin
Quinine + Clindamycin
4 types of tick-borne illness
Lyme
Babesiosus
Erlichiosis
RMSF
Tick-borne illness that causes hemolysis and anemia
Babesiosis - look at peripheral smear to diagnose
Tick-borne illness that has prominent rash that spreads centripetally and includes the palms and soles
RMSF
Tick-borne illness that causes flu-like symptoms and leukpenia/thrombocytopneia
Ehrlichiosis
This lung infection can present similarly to sarcoid
histoplasmosis
cough, hilar adenopathy, erythema nodosum, non-caseating granulomas, african american
sarcoid
two Tb-mimicking infections
histoplasmosis, blastomycosis
Infection of lungs in Mississipi and Ohio River basins
Histoplasmosis, also Blastomycosis
SW united states
Coccidioides
Symptoms of progressive disseminated histoplasmosis
febrile, wasting disroder, dyspnea, cough, papules, nodules, lymphadneopathy, hepatosplenomegaly, pancytopneaia, XR with hilar adenopathy and reticulonodular infiltrates
PPD size for HIV infected pt
> 5 mm is +
PPD size for pt with no risk factors
> 15 mm is +
If PPD is 8 mm for pt with HIV and CXR is normal, what to do?
Pt has latent Tb and needs 9 mo tx of Isoniazid and Pyridoxine
Why add pyridoxine to isoniazid tx?
prevent peripheral neuropathy
traveled to Africa, cyclical fever with nonspecific constitutional and GI symptoms, anemia, thrombocytopenia
Malaria
Symptoms within a week of exposure + muslce and oint pains, retrorbital pain, rash, leukopenia
dengue fever
skin and bone lesions, pulmonary symptoms, broad-based budding yeast, midwest
blastomycosis
IE in IVDU
tricuspid valve
Most common valve in IE
mitral valve
empiric tx of meningitis in immunocompromised pt
cefepime, vacno, ampicillin
IVDU with nodular cavitary infiltrates of lungs
tricuspid endocarditis with systemic embolization to lungs
lobar pneumonia, CAP
s pneumo
CD4 <200, diffuse infiltrates, indolent course
pneumocystis pneumonia
IVDU, fevers and SOB, holosystolic murmur that increase with inspiration, tricuspid valve, splinter hemorrhages
IE of tricuspid valve, diagnose with blood culture and TEE, empiric tx of vanco and tailor
Gonorrhea treatment
azithromycin + ceftriaxone
antibiotics with anaerobic coverage
amoxicillin, amox-clav, clindamycin
mono test
heterophile antibody test
mucopurulent urethral discharge
chlamydial urethritis