hem/onc Flashcards
Bone marrow infiltration of MM leads to …
osteolytic lesions, fractures, hypercalcemia, anemia
*** People with MM are susceptible to infections because…
hypogammaglobulinemia - manifest as recurrect respiratory and urinary tract infections
No spleen = infections with ___
encapsulated organisms (H flu, N meningitidis, S pneumo)
How does spleen help kill encapsulated bugs
anti-body mediated phagocystosis (opsonization) and anti-body mediated complement activation
*** Vaccines for asplenic patients
pneumococcal
meningococcal
H influenza type B
Normal B cell numbers but low Ig subtypes
Common Variable Immunodeficieny - cannot B cell isotype switch; at risk of recurrent GI and respiratory infections and autoimmune disease
Impaired chemotaxis
leukocyte adhesion deficiency
*** Impaired oxidative burst
Chronic Granulomatous Disease - will present with recurrent bacterial or fungal infections
New onset thrombocytopenia and arterial thrombosis after recently being anticoagulated for a DVT. What med was used?
Heparin, SE of HIT
*** Two medications used to increase appetite in cancer/dying patients
progesterone analogues (megestrol acetate) and corticosteroids
Sharp IgM spike Hyperviscosity syndrome (diplopia, tinnitus, HA) Neuropathy Bleeding Hepatosplenomegaly LAD
Waldenstrom Macroglobulinemia
LAD
Splenomegaly
B symptoms (fevers, night sweats, weight loss)
Non-Hodgkin Lymphoma
WBC of 60K with lymphocyte predominance
CLL
> 20% blasts on smear with bone pain, leukocytosis, anemia
acute leukemia
Which AML can be treated with VitA
M3, there will be auer rods on histology
