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IM > hem/onc > Flashcards

hem/onc Flashcards

1
Q

Bone marrow infiltration of MM leads to …

A

osteolytic lesions, fractures, hypercalcemia, anemia

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2
Q

*** People with MM are susceptible to infections because…

A

hypogammaglobulinemia - manifest as recurrect respiratory and urinary tract infections

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3
Q

No spleen = infections with ___

A

encapsulated organisms (H flu, N meningitidis, S pneumo)

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4
Q

How does spleen help kill encapsulated bugs

A

anti-body mediated phagocystosis (opsonization) and anti-body mediated complement activation

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5
Q

*** Vaccines for asplenic patients

A

pneumococcal
meningococcal
H influenza type B

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6
Q

Normal B cell numbers but low Ig subtypes

A

Common Variable Immunodeficieny - cannot B cell isotype switch; at risk of recurrent GI and respiratory infections and autoimmune disease

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7
Q

Impaired chemotaxis

A

leukocyte adhesion deficiency

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8
Q

*** Impaired oxidative burst

A

Chronic Granulomatous Disease - will present with recurrent bacterial or fungal infections

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9
Q

New onset thrombocytopenia and arterial thrombosis after recently being anticoagulated for a DVT. What med was used?

A

Heparin, SE of HIT

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10
Q

*** Two medications used to increase appetite in cancer/dying patients

A

progesterone analogues (megestrol acetate) and corticosteroids

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11
Q 
Sharp IgM spike
Hyperviscosity syndrome (diplopia, tinnitus, HA)
Neuropathy
Bleeding
Hepatosplenomegaly
LAD
A

Waldenstrom Macroglobulinemia

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12
Q

LAD
Splenomegaly
B symptoms (fevers, night sweats, weight loss)

A

Non-Hodgkin Lymphoma

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13
Q

WBC of 60K with lymphocyte predominance

A

CLL

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14
Q

> 20% blasts on smear with bone pain, leukocytosis, anemia

A

acute leukemia

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15
Q

Which AML can be treated with VitA

A

M3, there will be auer rods on histology

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16
Q

ppx intra-thecal chemo for ALL?

17
Q

tdt+

18
Q

9,22
Philadelphia Chromosome
Bcr-Abl

19
Q

CML targeted therapy

20
Q

Can CML undergo blast crisis and become AML?

21
Q

+ myeloperoxidase

22
Q

non-tender LAD +/- B symptoms

A

lymphoma, excisional biopsy

23
Q

differentiating cell-type HL vs NHL

A

Reed Sternberg Cells = HL

24
Q

Pel-Epstein Fevers

A

Cyclical fevers seen in HL

25
Q

chemo drug that causes oto toxicity and nephro toxicity

26
Q

*** chemo drug and hemorrhagic cystitis

A

cyclophosphamide

27
Q

This protein can lead to AKI in MM

A

Bence Jones

28
Q

Ig monoclonal spike, Bence Jones, Osteolytic activity

29
Q

SPEP + and BM biopsy with > 10% plasma cells

30
Q

Workup of MM

A

SPEP
UPEP
Skeletal Survey
Bone Marrow Biopsy

IM (17 decks)

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