Ibuprofen

Question 1

Classification

Answer 1

Nonsteroidal Anti-inflammatory Drug (NSAID)

Question 2

Mechanism of action

Answer 2

 Decreases inflammation, pain and fever though inhibition of cyclooxygenase activity and
prostaglandin synthesis

Question 3

Indications

Answer 3

 Treatment of mild to moderate pain
 Reduction in fever
 Anti-inflammatory

Question 4

Contraindications

Answer 4

 Hypersensitivity to
NSAIDs/salicylates
 ASA induced asthma
 Late pregnancy (3rd trimester)
 CVA or TBI in previous 24 hours
 Major burns
 Renal failure or solitary kidney
 Age under 6 months
 GI bleeding, peptic ulcer disease
 > 65 years of age

Question 5

Dose

Answer 5

 Adult
o 200 - 600 mg PO q 6 – 8 h
 Pediatric (> 6 months)
o 7.5 mg/kg PO 6 – 8 h (For children over 12 use adult dosing)

Question 6

Side Effects

Answer 6

Dizziness, drowsiness, light headedness, peripheral edema, diarrhea, nausea and
vomiting

Question 7

Precautions

Answer 7

 Renal impairment
 History of GI bleeds
 CHF