IBS Treatment Mechanisms of Action Flashcards
0
Q
Loperamide
A
Opiate
1
Q
Linaclotide
A
Binds Guanylate cyclase receptor, activating CFTR, increasing fluid secretion
2
Q
Lubiprostone
A
Activates Type 2 chloride channel, increasing motility
3
Q
Bulk forming laxatives
A
yep
4
Q
Amitryptyline
A
Anticholinergic properties reduce stool frequenchy and liquidity
Prevent painful sensation
5
Q
Desipramine
A
Anticholinergic properties reduce stool frequency and liquidity
Prevent painful sensation
6
Q
SSRI’s
A
Decrease reuptake of 5HT, increase afferent activity and increase peristalsis
7
Q
Alosetron
A
Prevent 5HT3 afferent pain sensation via extrinsic sensory neurons, reducing bloating, nausea and pain
Inhibits colonic motility
8
Q
Tegaserod
A
5HT4 agonist, which stimulates proximal bowel contraction and distal bowel relaxation
