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Gastrointestinal - Pharmacology > Antidiarrheals Mechanism of Action > Flashcards

Antidiarrheals Mechanism of Action Flashcards

0
Q

Loperamide

A

Inhibits presynaptic cholinergic nerves in the myenteric and submucosal plexi, leading to increased transit time and water absorption

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1
Q

Diphenoxylate

A

Inhibit presynaptic cholinergic nerves in myenteric and submucosal plexi, leading to increased transit time and water absorption
CNS effects

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2
Q

Cholestyramine

A

Bile salt sequestrant

Binds excess bile acids, decreasing secretory diarrhea

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3
Q

Colestipol

A

Bile acid sequestrant

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4
Q

Bismuth subsalicylate

A

Subsalicylate decreases prostaglandins and chloride secretion

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5
Q

Crofelemer

A

Inhibits cAMP stimulated CFTR and calcium activated CL channels on luminal membrane

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6
Q

Octreotide

A

Similar actions to somatostatin
Reduces intestinal, pancreatic and gallbladder secretion
Slows motility
Reduces splanchnic blood flow

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Gastrointestinal - Pharmacology (15 decks)

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