IBR Flashcards
what is IBR?
the most common clinical manifestation of dx that occurs during 1ary infection w BoHV-1
what does IBR stand for?
infectious bovine rhinotracheitis
what are the 3 subtypes of BoHV1?
BoHV-1.1 = mainly causes IBR & can cause abortion BoHV-1.2a = mainly cause IPV/IPB & can cause abortion BoHV-1.2b = mainly cause IPV/IPB but does NOT cause abortion
what does IPV & IPB stand for?
infectious pustular vulvovaginitis
infectious pustular balanophosthitis
what are the main glycoproteins which ab are produced against for BoHV-1?
glycoprotein E & B
every animal that has 1ary infection will go on to become latent: T/F?
true
stress can cause reactivation of BoHV-1, resulting in secondary infection: T/F
true
does virus shedding occur again at secondary infection?
yes
are there any CS for 2dary infection?
usually no CS
define naive animal
never been exposed to virus
no Ab present in blood unless MDA
what is the source of virus for 1ary infections?
other BoHV-1 infected animals
how is virus spread for 1ary infections?
mainly by direct contact:
- resp secretions = nose to nose contact & aerosol w/i 3-5m
- repro secretions (semen & female repro fluid)
- indirect spread (fluid on outer clothing) has been documented
what CS are there for 1ary infections?
dullness & reduced appetite pyrexia sudden reduced milk pdtn conjunctivitis nasal & ocular discharge pharyngitis/tracheitis (URT signs) rapid & loud breathing sometimes w cough abortion (if virus crosses placenta) embryo death (documented in maiden heifers) neuro menigitis in neonatal calves
what are the viruses that can be involved in bovine resp dx complex?
PI3 RSV BoHV-1 BVDV mycoplasma pasteurella
what kind of ab response will there be for 1ary infections?
fast & sustained
where does the virus become latent in?
nerve ganglion
-usually dorsal root ganglion of trigeminal nerve w resp infection
does the ab titre persist in latent infections?
yes
what can stimulate reactivation of latent infection?
stress:
- calving
- transport
- high dose dexamethasone tx
- lameness
- dx
- nutritional stress
what CS are there in latent infection?
absent/v mild
when will ab titre not be persistent in latent infection?
if infected during period of MDA cover - can lead to latent infection w/o circulating ab
sero-ve latent carrier
diagnosis for BoHV-1?
ocular conjunctival swab or guarded nasopharyngeal swab - direct test (ACUTE!) send to lab for: PCR virus isolation FAT (fluorescent ab test) serological ab testing
what does serological ab testing test for?
ab to gE/gB
not useful for diagnosis of acute illness
ESSENTIAL for diagnosis & control @ herd lvl
tx for BoHV-1? (acute)
NSAIDs
abs if animal @ risk of 2ary infection
consider vax in the face of infection if confirmed diagnosis
what are vax licensed to do?
reduce severity of CS during 1ary infection
reduce shedding during 1ary infection
reduce likelihood & duration of shedding from reactivation
