IBD meds Flashcards

1
Q

Alosetron (Lotronex) Misc

A

FDA approval recently withdrawn

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2
Q

Sulfasalazine (Azulfidine) Class

A

Anti-inflammatory

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3
Q

Olsalazine (Dipentum) Class

A

Anti-inflammatory

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4
Q

Mesalamine (Pentasa) Class

A

Anti-inflammatory

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5
Q

Prednisone (Decadron) Class

A

Corticosteroid

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6
Q

Azathioprine (Imuran) Class

A

Immunosupressive

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7
Q

Cyclosporine (Sandimmune) Class

A

Immunosupressive

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8
Q

Infliximab (Remicade) Class

A

MAb Immunosupressive

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9
Q

Sulfasalazine (Azulfidine) MOA

A

Work from lumen to reduce inflammation

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10
Q

Olsalazine (Dipentum) MOA

A

Work from lumen to reduce inflammation; 5-ASA dimer

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11
Q

Mesalamine (Pentasa) MOA

A

Work from lumen to reduce inflammation

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12
Q

Azathioprine (Imuran) MOA

A

Purine antimetabolite; interferes with DNA synthesis

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13
Q

Cyclosporine (Sandimmune) MOA

A

Suppresses T helper and T suppressor lymphocytes

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14
Q

Infliximab (Remicade) MOA

A

Binds and neutralizes TNFa

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15
Q

Sulfasalazine (Azulfidine) Therapies

A

Acute IBD (UC)

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16
Q

Olsalazine (Dipentum) Therapies

A

Acute IBD (UC)

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17
Q

Mesalamine (Pentasa) Therapies

A

Acute IBD (UC)

18
Q

Prednisone (Decadron) Therapies

A

Acute IBD, chronic IBD

19
Q

Azathioprine (Imuran) Therapies

A

Chronic IBD

20
Q

Cyclosporine (Sandimmune) Therapies

A

Chronic IBD

21
Q

Infliximab (Remicade) Therapies

A

Chronic IBD

22
Q

Sulfasalazine (Azulfidine) SE

A

Toxicity coming from systemic absorption of sulfapyridine

23
Q

Olsalazine (Dipentum) SE

A

Less toxicity than sulfasalzine

24
Q

Sulfasalazine (Azulfidine) Misc

A

Sulfapyridine conjugated to 5-ASA to prevent its degradation, improve its absorption; bond broken in large bowel by bacteria

25
Olsalazine (Dipentum) Misc
Broken down into bowel by bacteria into 2 moleules of 5-ASA
26
Mesalamine (Pentasa) Misc
Delayed release 5-ASA, for terminal ileum, colon
27
Prednisone (Decadron) Misc
Can be given systemically or as enemas
28
Dicyclomine HCl (Bentyl) Class
Anticholinergic (antispasmodic)
29
Hyoscyamine sulfate (Levsin) Class
Anticholinergic (antispasmodic)
30
Alosetron (Lotronex) Class
Serotonergic antagonist
31
Tegaserod maleate (Zelnorm) Class
Serotonergic agonist
32
Dicyclomine HCl (Bentyl) MOA
Blocks cholinergic action
33
Hyoscyamine sulfate (Levsin) MOA
Blocks cholinergic action
34
Alosetron (Lotronex) MOA
Blocks 5HT3
35
Tegaserod maleate (Zelnorm) MOA
Hits 5HT4
36
Dicyclomine HCl (Bentyl) THerapies
Reduce spasm in irritable bowel syndrome
37
Hyoscyamine sulfate (Levsin) Therapies
Reduce spasm in irritable bowel syndrome
38
Alosetron (Lotronex) Therapies
Diarrhea in irritable bowel syndrome
39
Tegaserod maleate (Zelnorm) Therapies
Constipation in irritable bowel syndrome
40
Alosetron (Lotronex) SE
Ischemic bowel, Constipation
41
Tegaserod maleate (Zelnorm) Misc
FDA approval recently withdrawn
42
Alosetron (Lotronex) Misc
FDA approval recently withdrawn