GERD and Ulcer Meds Flashcards
1
Q
Metochlopramide (Reglan) Misc
A
Can be used once/day for good effects
2
Q
Calcium carbonate (Rolaids, Tums) Class
A
Antacid
3
Q
Sodium bicarbonate Class
A
Antacid
4
Q
Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) Class
A
Antacid
5
Q
Aluminum hydroxide (Alternagel) Class
A
Antacid
6
Q
Atropine sulfate (Donnatol) Class
A
Anticholinergics
7
Q
Propantheline (Pro-Banthine); Metantheline bromide Class
A
Anticholinergics
8
Q
Cimetidine (Tagamet) Class
A
Histamine (H2) receptor blocker
9
Q
Ranitidine (Zantac) Class
A
Histamine (H2) receptor blocker
10
Q
Famotidine (Pepcid) Class
A
Histamine (H2) receptor blocker
11
Q
Nizatidine (Axid) Class
A
Histamine (H2) receptor blocker
12
Q
Misoprostol (Cytotec) Class
A
ProstaglandinE analog
13
Q
Omeprazole (Prilosec) Class
A
H/K/ATPase inhibitor
14
Q
Lansoprazole (Prevacid) Class
A
H/K/ATPase inhibitor
15
Q
Rabeprazole (AcipHex) Class
A
H/K/ATPase inhibitor
16
Q
Pantoprazole (Protonix) Class
A
H/K/ATPase inhibitor
17
Q
Esomeprazole (Nexium) Class
A
H/K/ATPase inhibitor
18
Q
Sucralfate (Carafate) Class
A
Mechanical protectors
19
Q
Bismuth salts (Pepto-Bismol) Class
A
Mechanical protectors
20
Q
Metochlopramide (Reglan) Class
A
Promotility agent (dopamine antagonist
21
Q
Cisapride (Propulsid) Class
A
Promotility agent (dopamine antagonist
22
Q
Domperidone (Motilium) Class
A
Promotility agent
23
Q
Calcium carbonate (Rolaids, Tums) MOA
A
Chemical reaction
24
Q
Sodium bicarbonate MOA
A
Chemical reaction
25
Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) MOA
Chemical reaction
26
Aluminum hydroxide (Alternagel) MOA
Chemical reaction
27
Atropine sulfate (Donnatol) MOA
Reduce acid secretion, reduce spasm
28
Propantheline (Pro-Banthine); Metantheline bromide MOA
Reduce acid secretion, reduce spasm
29
Cimetidine (Tagamet) MOA
Inhibit 50-80% of 24 hour acid production
30
Ranitidine (Zantac) MOA
Inhibit 50-80% of 24 hour acid production
31
Famotidine (Pepcid) MOA
Inhibit 50-80% of 24 hour acid production
32
Nizatidine (Axid) MOA
Inhibit 50-80% of 24 hour acid production
33
Misoprostol (Cytotec) MOA
Decrease acid production, increase mucous and bicarbonate secretion
34
Omeprazole (Prilosec) MOA
Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don't take with antacids)
35
Lansoprazole (Prevacid) MOA
Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don't take with antacids)
36
Rabeprazole (AcipHex) MOA
Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don't take with antacids)
37
Pantoprazole (Protonix) MOA
Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don't take with antacids)
38
Esomeprazole (Nexium) MOA
Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don't take with antacids)
39
Sucralfate (Carafate) MOA
Coat the ulcer crater, increase mucosal resistance (requires acid environment)
40
Bismuth salts (Pepto-Bismol) MOA
Coat the ulcer crater, increase mucosal resistance
41
Metochlopramide (Reglan) MOA
Increase motor tone in lower esophageal sphincter (prevent reflux) and stomch (esp. antrum: improves gastric emptying); peripheral (stomach) and CNS (vomiting, via CRTZ) dopamine antagonist
42
Cisapride (Propulsid) MOA
Increase motor tone in lower esophageal sphincter and stomch
43
Domperidone (Motilium) MOA
Improves gastric tone
44
Calcium carbonate (Rolaids, Tums) Therapies
Ulcer treatment; GERD
45
Sodium bicarbonate Therapies
Ulcer treatment; GERD
46
Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) Therapies
Ulcer treatment; GERD
47
Aluminum hydroxide (Alternagel) Therapies
Ulcer treatment; GERD
48
Atropine sulfate (Donnatol) Therapies
Ulcer treatment
49
Propantheline (Pro-Banthine); Metantheline bromide Therapies
Ulcer treatment (taken 15-30 minutes before meals, and before bed)
50
Cimetidine (Tagamet) Therapies
Ulcer treatment (first class to satisfy all 4 requirements); prophylactically for stress ulcers; GERD
51
Ranitidine (Zantac) Therapies
Ulcer treatment (satisfy all 4 requirements); prophylactically for stress ulcers; GERD
52
Famotidine (Pepcid) Therapies
Ulcer treatment (satisfy all 4 requirements); prophylactically for stress ulcers; GERD
53
Nizatidine (Axid) Therapies
Ulcer treatment (satisfy all 4 requirements); prophylactically for stress ulcers; GERD
54
Misoprostol (Cytotec) Therapies
Ulcer treatment when prostaglandin production decreased (RA patients taking lots of NSAIDs)
55
Omeprazole (Prilosec) Therapies
Ulcer treatment, treatment for H. pylori; GERD
56
Lansoprazole (Prevacid) Therapies
Ulcer treatment, treatment for H. pylori; GERD
57
Rabeprazole (AcipHex) Therapies
Ulcer treatment; GERD
58
Pantoprazole (Protonix) Therapies
Ulcer treatment; GERD
59
Esomeprazole (Nexium) Therapies
Ulcer treatment; GERD
60
Sucralfate (Carafate) Therapies
Ulcer treatment, treatment for H. pylori
61
Bismuth salts (Pepto-Bismol) Therapies
Ulcer treatment, treatment for H. pylori
62
Metochlopramide (Reglan) Therapies
GERD, anti-emetic, gastroparesis
63
Cisapride (Propulsid) Therapies
GERD, gastroparesis
64
Domperidone (Motilium) Therapies
Gastroparesis
65
Calcium carbonate (Rolaids, Tums) SE
Milk-alkali syndrome, nephrocalcinosis, "rebound" acidity, digitalis antagonism, Constipating effects
66
Sodium bicarbonate SE
Systemic alkalosis, Enhanced effects of amphetamine, quinidine, and cinchophen
67
Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) SE
Diarrhea (laxative effects), Hypokalemia, hypermagnesemia, iron deficiency
68
Aluminum hydroxide (Alternagel) SE
Phosphate depletion and sequelae (weakness, anemia, tetany, apnea), Constipation
69
Atropine sulfate (Donnatol) SE
Anticholinergic effects
70
Propantheline (Pro-Banthine); Metantheline bromide SE
Anticholinergic effects
71
Cimetidine (Tagamet) SE
Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination
72
Ranitidine (Zantac) SE
Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination
73
Famotidine (Pepcid) SE
Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination
74
Nizatidine (Axid) SE
Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination
75
Omeprazole (Prilosec) SE
Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)
76
Lansoprazole (Prevacid) SE
Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)
77
Rabeprazole (AcipHex) SE
Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)
78
Pantoprazole (Protonix) SE
Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)
79
Esomeprazole (Nexium) SE
Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)
80
Sucralfate (Carafate) SE
Aluminum toxicity possible in renal failure
81
Bismuth salts (Pepto-Bismol) SE
Aluminum toxicity possible in renal failure; turns bowel movements (and sometimes tongues) black
82
Metochlopramide (Reglan) SE
Hand tremor if used 4X/day (optimum use); possible extra-pyramidal symptoms, but not so severe
83
Cisapride (Propulsid) SE
Sudden cardiac death, Not really used much anymore
84
Sodium bicarbonate Misc
Rarely used due to causing systemic alkalosis
85
Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) Misc
Magnesium toxicity mostly in presence of renal disease; liquid-based, so act fast
86
Aluminum hydroxide (Alternagel) Misc
Safe for use in patients with renal failure (bonus: helps eliminate phosphate)
87
Atropine sulfate (Donnatol) Misc
AKA, belladonna; contraindications: known pyloric obstruction, hiatal hernia, or peptic esophagitis (not used much)
88
Propantheline (Pro-Banthine); Metantheline bromide Misc
Contraindications: known pyloric obstruction, hiatal hernia, or peptic esophagitis (not used much)
89
Cimetidine (Tagamet) Misc
One dose as effective as multiple; binds and interferes with P450
90
Ranitidine (Zantac) Misc
One dose as effective as multiple; binds and interferes with P450
91
Famotidine (Pepcid) Misc
One dose as effective as multiple
92
Nizatidine (Axid) Misc
One dose as effective as multiple
93
Misoprostol (Cytotec) Misc
Not very effective, since endogenous prostaglandin levels are already high in duodenal ulcer patients
94
Omeprazole (Prilosec) Misc
For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin; large P450 interference; lowest bioavailability
95
Lansoprazole (Prevacid) Misc
For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin; some P450 interference; great bioavailability
96
Rabeprazole (AcipHex) Misc
Moderate P450 interference
97
Pantoprazole (Protonix) Misc
No P450 interference; great bioavailability
98
Esomeprazole (Nexium) Misc
Some (?) P450 interference
99
Sucralfate (Carafate) Misc
For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin; big pill, need to take 4 times per day
100
Bismuth salts (Pepto-Bismol) Misc
For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin
101
Metochlopramide (Reglan) Misc
Can be used once/day for good effects
