GERD and Ulcer Meds Flashcards by Sarah Moore | Brainscape

Q

Metochlopramide (Reglan) Misc

A

Can be used once/day for good effects

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Q

Calcium carbonate (Rolaids, Tums) Class

A

Antacid

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Q

Sodium bicarbonate Class

A

Antacid

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Q

Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) Class

A

Antacid

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Q

Aluminum hydroxide (Alternagel) Class

A

Antacid

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Q

Atropine sulfate (Donnatol) Class

A

Anticholinergics

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Q

Propantheline (Pro-Banthine); Metantheline bromide Class

A

Anticholinergics

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Q

Cimetidine (Tagamet) Class

A

Histamine (H2) receptor blocker

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Q

Ranitidine (Zantac) Class

A

Histamine (H2) receptor blocker

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Q

Famotidine (Pepcid) Class

A

Histamine (H2) receptor blocker

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Q

Nizatidine (Axid) Class

A

Histamine (H2) receptor blocker

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Q

Misoprostol (Cytotec) Class

A

ProstaglandinE analog

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Q

Omeprazole (Prilosec) Class

A

H/K/ATPase inhibitor

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Q

Lansoprazole (Prevacid) Class

A

H/K/ATPase inhibitor

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Q

Rabeprazole (AcipHex) Class

A

H/K/ATPase inhibitor

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Q

Pantoprazole (Protonix) Class

A

H/K/ATPase inhibitor

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Q

Esomeprazole (Nexium) Class

A

H/K/ATPase inhibitor

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Q

Sucralfate (Carafate) Class

A

Mechanical protectors

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Q

Bismuth salts (Pepto-Bismol) Class

A

Mechanical protectors

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Q

Metochlopramide (Reglan) Class

A

Promotility agent (dopamine antagonist

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Q

Cisapride (Propulsid) Class

A

Promotility agent (dopamine antagonist

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Q

Domperidone (Motilium) Class

A

Promotility agent

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Q

Calcium carbonate (Rolaids, Tums) MOA

A

Chemical reaction

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Q

Sodium bicarbonate MOA

A

Chemical reaction

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Q

Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) MOA

A

Chemical reaction

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Q

Aluminum hydroxide (Alternagel) MOA

A

Chemical reaction

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Q

Atropine sulfate (Donnatol) MOA

A

Reduce acid secretion, reduce spasm

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Q

Propantheline (Pro-Banthine); Metantheline bromide MOA

A

Reduce acid secretion, reduce spasm

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Q

Cimetidine (Tagamet) MOA

A

Inhibit 50-80% of 24 hour acid production

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Q

Ranitidine (Zantac) MOA

A

Inhibit 50-80% of 24 hour acid production

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Q

Famotidine (Pepcid) MOA

A

Inhibit 50-80% of 24 hour acid production

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Q

Nizatidine (Axid) MOA

A

Inhibit 50-80% of 24 hour acid production

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Q

Misoprostol (Cytotec) MOA

A

Decrease acid production, increase mucous and bicarbonate secretion

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Q

Omeprazole (Prilosec) MOA

A

Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don’t take with antacids)

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Q

Lansoprazole (Prevacid) MOA

A

Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don’t take with antacids)

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Q

Rabeprazole (AcipHex) MOA

A

Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don’t take with antacids)

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Q

Pantoprazole (Protonix) MOA

A

Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don’t take with antacids)

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Q

Esomeprazole (Nexium) MOA

A

Inhibit >90% of 24 hour acid secretion (better than H2 antagonists); requires acid environment to activate (don’t take with antacids)

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Q

Sucralfate (Carafate) MOA

A

Coat the ulcer crater, increase mucosal resistance (requires acid environment)

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Q

Bismuth salts (Pepto-Bismol) MOA

A

Coat the ulcer crater, increase mucosal resistance

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Q

Metochlopramide (Reglan) MOA

A

Increase motor tone in lower esophageal sphincter (prevent reflux) and stomch (esp. antrum: improves gastric emptying); peripheral (stomach) and CNS (vomiting, via CRTZ) dopamine antagonist

Q

Cisapride (Propulsid) MOA

A

Increase motor tone in lower esophageal sphincter and stomch

Q

Domperidone (Motilium) MOA

A

Improves gastric tone

Q

Calcium carbonate (Rolaids, Tums) Therapies

A

Ulcer treatment; GERD

Q

Sodium bicarbonate Therapies

A

Ulcer treatment; GERD

Q

Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) Therapies

A

Ulcer treatment; GERD

Q

Aluminum hydroxide (Alternagel) Therapies

A

Ulcer treatment; GERD

Q

Atropine sulfate (Donnatol) Therapies

A

Ulcer treatment

Q

Propantheline (Pro-Banthine); Metantheline bromide Therapies

A

Ulcer treatment (taken 15-30 minutes before meals, and before bed)

Q

Cimetidine (Tagamet) Therapies

A

Ulcer treatment (first class to satisfy all 4 requirements); prophylactically for stress ulcers; GERD

Q

Ranitidine (Zantac) Therapies

A

Ulcer treatment (satisfy all 4 requirements); prophylactically for stress ulcers; GERD

Q

Famotidine (Pepcid) Therapies

A

Ulcer treatment (satisfy all 4 requirements); prophylactically for stress ulcers; GERD

Q

Nizatidine (Axid) Therapies

A

Ulcer treatment (satisfy all 4 requirements); prophylactically for stress ulcers; GERD

Q

Misoprostol (Cytotec) Therapies

A

Ulcer treatment when prostaglandin production decreased (RA patients taking lots of NSAIDs)

Q

Omeprazole (Prilosec) Therapies

A

Ulcer treatment, treatment for H. pylori; GERD

Q

Lansoprazole (Prevacid) Therapies

A

Ulcer treatment, treatment for H. pylori; GERD

Q

Rabeprazole (AcipHex) Therapies

A

Ulcer treatment; GERD

Q

Pantoprazole (Protonix) Therapies

A

Ulcer treatment; GERD

Q

Esomeprazole (Nexium) Therapies

A

Ulcer treatment; GERD

Q

Sucralfate (Carafate) Therapies

A

Ulcer treatment, treatment for H. pylori

Q

Bismuth salts (Pepto-Bismol) Therapies

A

Ulcer treatment, treatment for H. pylori

Q

Metochlopramide (Reglan) Therapies

A

GERD, anti-emetic, gastroparesis

Q

Cisapride (Propulsid) Therapies

A

GERD, gastroparesis

Q

Domperidone (Motilium) Therapies

A

Gastroparesis

Q

Calcium carbonate (Rolaids, Tums) SE

A

Milk-alkali syndrome, nephrocalcinosis, “rebound” acidity, digitalis antagonism, Constipating effects

Q

Sodium bicarbonate SE

A

Systemic alkalosis, Enhanced effects of amphetamine, quinidine, and cinchophen

Q

Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) SE

A

Diarrhea (laxative effects), Hypokalemia, hypermagnesemia, iron deficiency

Q

Aluminum hydroxide (Alternagel) SE

A

Phosphate depletion and sequelae (weakness, anemia, tetany, apnea), Constipation

Q

Atropine sulfate (Donnatol) SE

A

Anticholinergic effects

Q

Propantheline (Pro-Banthine); Metantheline bromide SE

A

Anticholinergic effects

Q

Cimetidine (Tagamet) SE

A

Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination

Q

Ranitidine (Zantac) SE

A

Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination

Q

Famotidine (Pepcid) SE

A

Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination

Q

Nizatidine (Axid) SE

A

Rebound acidity if stopped suddenly, Uncommon; headache, lethargy, confusion, depression, and hallucination

Q

Omeprazole (Prilosec) SE

A

Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)

Q

Lansoprazole (Prevacid) SE

A

Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)

Q

Rabeprazole (AcipHex) SE

A

Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)

Q

Pantoprazole (Protonix) SE

A

Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)

Q

Esomeprazole (Nexium) SE

A

Headache, gynecomastia, gastric hyperplasia in humans and carcinoid tumors in rats long term (do not use long-term)

Q

Sucralfate (Carafate) SE

A

Aluminum toxicity possible in renal failure

Q

Bismuth salts (Pepto-Bismol) SE

A

Aluminum toxicity possible in renal failure; turns bowel movements (and sometimes tongues) black

Q

Metochlopramide (Reglan) SE

A

Hand tremor if used 4X/day (optimum use); possible extra-pyramidal symptoms, but not so severe

Q

Cisapride (Propulsid) SE

A

Sudden cardiac death, Not really used much anymore

Q

Sodium bicarbonate Misc

A

Rarely used due to causing systemic alkalosis

Q

Magnesium hydroxide, magnesium carbonate (Maalox, Mylanta) Misc

A

Magnesium toxicity mostly in presence of renal disease; liquid-based, so act fast

Q

Aluminum hydroxide (Alternagel) Misc

A

Safe for use in patients with renal failure (bonus: helps eliminate phosphate)

Q

Atropine sulfate (Donnatol) Misc

A

AKA, belladonna; contraindications: known pyloric obstruction, hiatal hernia, or peptic esophagitis (not used much)

Q

Propantheline (Pro-Banthine); Metantheline bromide Misc

A

Contraindications: known pyloric obstruction, hiatal hernia, or peptic esophagitis (not used much)

Q

Cimetidine (Tagamet) Misc

A

One dose as effective as multiple; binds and interferes with P450

Q

Ranitidine (Zantac) Misc

A

One dose as effective as multiple; binds and interferes with P450

Q

Famotidine (Pepcid) Misc

A

One dose as effective as multiple

Q

Nizatidine (Axid) Misc

A

One dose as effective as multiple

Q

Misoprostol (Cytotec) Misc

A

Not very effective, since endogenous prostaglandin levels are already high in duodenal ulcer patients

Q

Omeprazole (Prilosec) Misc

A

For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin; large P450 interference; lowest bioavailability

Q

Lansoprazole (Prevacid) Misc

A

For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin; some P450 interference; great bioavailability

Q

Rabeprazole (AcipHex) Misc

A

Moderate P450 interference

Q

Pantoprazole (Protonix) Misc

A

No P450 interference; great bioavailability

Q

Esomeprazole (Nexium) Misc

A

Some (?) P450 interference

Q

Sucralfate (Carafate) Misc

A

For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin; big pill, need to take 4 times per day

Q

Bismuth salts (Pepto-Bismol) Misc

A

For H. pylori treatments, used with tetracycline, metronidazole, and clarithromycin

Q

Metochlopramide (Reglan) Misc

A

Can be used once/day for good effects