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Pharm Unit 6: Misc > Chelation > Flashcards

Chelation Flashcards

1
Q

Deferoxamine (Desferal) MISC

A

Can only treat for 24 hours before acute lung injury manifests

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2
Q

British Anti-Lewisite (Dimercaprol) Class

A

Dithiol

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3
Q

2,3-dimercaptosuccinic acid (Succimer) Class

A

Dithiol

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4
Q

British Anti-Lewisite (Dimercaprol) MOA

A

Forms stable chelate via electron pair donation and coordination with metal ion; solubilized in peanut oil

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5
Q

2,3-dimercaptosuccinic acid (Succimer) MOA

A

Coordinate bonding to sulfur (arsenic and mercury) or sulfur and oxygen (lead and cadmium)

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6
Q

Edetate calcium disodium (EDTA) MOA

A

Displacement of calcium by lead

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7
Q

Ferric hexacyanoferrate /Prussian Blue (Radiogardase) MOA

A

Stays in gut and not absorbed until it grabs metal; goes into gut and is excreted that way

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8
Q

Deferoxamine (Desferal) MOA

A

Chelates free iron and iron transported between transferrin and ferritin

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9
Q

British Anti-Lewisite (Dimercaprol) Therapies

A

Arsenic, lead, inorganic mercury poisoning

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10
Q

2,3-dimercaptosuccinic acid (Succimer) Therapies

A

Arsenic, lead, mercury, cadmium poisoning

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11
Q

Edetate calcium disodium (EDTA) Therapies

A

Lead poisoning

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12
Q

Ferric hexacyanoferrate /Prussian Blue (Radiogardase) Therapies

A

Thallium and radioactive cesium poisoning

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13
Q

Deferoxamine (Desferal) Therapies

A

Acute iron poisoning; chronic iron overload

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14
Q

British Anti-Lewisite (Dimercaprol) SE

A

Renal toxicity (unless urine is alkalinized, due to dissociation), Pain at injection site (IM); nausea, vomiting; increases in BP and HR

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15
Q

2,3-dimercaptosuccinic acid (Succimer) Se

A

Mild ALT/AST elevation (usually only 2 - 3 times upper limit normal, and transient, Well tolerated; nausea, vomiting, flatuus, diarrhea

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16
Q

Edetate calcium disodium (EDTA) SE

A

Malaise, fever, Renal toxicity (proximal tubules, distal tubules, glomeruli); ALT/AST increase

17
Q

Ferric hexacyanoferrate /Prussian Blue (Radiogardase) SE

A

Well tolerated; not absorbed after oral dosing into systemic circulation (this is pretty unique)

18
Q

Deferoxamine (Desferal) SE

A

Rate-related hypotension; anaphylactoid reactions; yersinia enterocolitis; acute lung injury/ARDS

19
Q

British Anti-Lewisite (Dimercaprol) MISC

A

Given IV or IM; allergic implications (peanut oil); need to start using ASAP

20
Q

2,3-dimercaptosuccinic acid (Succimer) MISC

A

Given orally onlu in US;given IV in other countries with more severe adverse events secondary to IV administration

21
Q

Edetate calcium disodium (EDTA) MISC

A

Given IV; DO NOT CONFUSE WITH Na2EDTA (can lead to life-threatening hypocalcemia); if given in lead encephalopathy, there is a potential to cause lead redistribution into the brain; BAL must be given before this in that scenario

22
Q

Ferric hexacyanoferrate /Prussian Blue (Radiogardase) MISC

A

Some concern that cyanide is liberated from Prussian Blue, however the amount released appears to be quantitatively minimal & not clinically significant

23
Q

Deferoxamine (Desferal) MISC

A

Can only treat for 24 hours before acute lung injury manifests

Pharm Unit 6: Misc (9 decks)

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