Anti-Emetic Drugs Flashcards
Odansetron (Zofran) Misc
Very safe for vomiting of any type (including drug-induced); can even be given to 6 month-old
Prochlorperazine (Compazine) Class
Phenothiazines (neuroleptic class)
Promethazine (Phenergan) Class
Phenothiazines (neuroleptic class)
Trimethobenzamide (Tigan) Class
Benzamide derivitive
Odansetron (Zofran) Class
Serotonin (5HT3) receptor antagonists
Granesitron (Kytril) Class
Serotonin (5HT3) receptor antagonists
Dolasetron (Anzemet) Class
Serotonin (5HT3) receptor antagonists
Prochlorperazine (Compazine) MOA
Probable CNS interaction with dopaminergic receptor-antagonist (leading to reduction of stimulation in the CRTZ in the medulla)
Promethazine (Phenergan) MOA
Antihistaminic (H1 receptor), anticholinergic
Trimethobenzamide (Tigan) MOA
Unknown effect on CRTZ
Tetrahydrocannabinol (Nabilone) MOA
Suppresses CRTZ, probably by anticholinergic mechanism
Odansetron (Zofran) MOA
Blocks serotonin at 5HT3 receptor (in central CRTZ)
Granesitron (Kytril) MOA
Blocks serotonin at 5HT3 receptor (in central CRTZ)
Dolasetron (Anzemet) MOA
Blocks serotonin at 5HT3 receptor (in central CRTZ)
Prochlorperazine (Compazine) Therapies
Anti-emetic
Promethazine (Phenergan) Therapies
Anti-emetic
Trimethobenzamide (Tigan) Therapies
Anti-emetic
Tetrahydrocannabinol (Nabilone) Therapies
Anti-emetic
Odansetron (Zofran) Therapies
Anti-emetic
Granesitron (Kytril) Therapies
Anti-emetic
Dolasetron (Anzemet) Therapies
Anti-emetic
Prochlorperazine (Compazine) SE
Largely extra-pyramidal (torticollis!)
Promethazine (Phenergan) SE
Somnolence (especially in the elderly)
Trimethobenzamide (Tigan) SE
Low-side effect profile; possible extra-pyramidal symptoms, but not so severe
