IBD Flashcards
1
Q
smoking with IBD
A
- nicotine is bad for CD but helps with UC
2
Q
bacteria as a trigger for IBD
A
- IBD involves a loss of tolerance for normal GI microflora
- IBD patients have altered composition of commensal enteric bacteria
3
Q
symptoms of UC
A
- mucosal ulceration of the colon,
- continuous inflammation
- generally affects the colon
- mucosal inflammation
- fistulas and strictures seldom
- risk of colorectal cancer
- extraintestinal manifestations
- lower risk for smokers
- granulomas extremely rare
4
Q
symptoms of CD
A
- patchy inflammation
- mouth to anus involvement
- transmural inflammation
- fistulas and strictures common
- risk of cancer
- extraintestinal manifestations
- higher risk for smokers
- can have granulomas (50%)
5
Q
extraintestinal manifestations of IBD
A
- peripheral arthritis: arthralgia more common in CD
- axial arthritis: ankylosing spondylitis more common in UC
- osteoporosis more common in CD
- renal, dermatological, eye, thromboembolic, hepatic complications
6
Q
ankylosing spondylitis
A
- clinical course independent of bowel disease
- associated with HLA-B27
- bamboo spine on plain X-rays
7
Q
sacroilitis
A
- independent of bowel disease
- associated with HLA-B27
8
Q
peripheral arthritis
A
- activity parallels bowel disease activity
- mono-articular in IBD
9
Q
nephrolithiasis
A
- urate stones associated with UC
- calcium oxalate stones associated with CD
10
Q
obstructive hydronephritis
A
- associated with CD but not UC
11
Q
erythema nodusum
A
- red, raised, painful nodular rash
- directly related to bowel disease
12
Q
pyoderma gangrenosum
A
- ulcerates
- course is independent of bowel disease
13
Q
uveitis
A
- independent of bowel disease
- associated with HLA-B27
- painful, injected eye with synechiae and opacity in the anterior chamber
14
Q
episcleritis
A
- painful, injected eye
- independent of bowel disease
15
Q
primary sclerosing cholangitis
A
- 70% of PSC patients have UC
- associated with DRW-52A haplotype
