Digestion and Absorption Flashcards

1
Q

digestion in the mouth

A
  • lipids - lingual lipase
  • carbs - alpha amylase
  • protein - none
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2
Q

digestion in the stomach

A
  • lipids - gastric lipase
  • carbs - none
  • protein - HCl denatures secondary and tertiary structures, pepsin is activated
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3
Q

digestion in the intestine

A
  • lipids - pancreatic lipase, colipase, cholesterol esterases, phospholipase A2
  • carbs - pancreatic amylase, glucoamylase, sucrase-isomaltase, trehalase, lactase-glucosylceramidase
  • protein - trypsin, chymotrypsin, elastase, carboxypeptidase, aminopeptidases
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4
Q

characteristics of salivary alpha amylase

A
  • endoglucosidase
  • hydrolyzes alpha 1,4 bonds
  • inactivated by low pH of the stomach
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5
Q

characteristics of glycoamylase

A
  • exoglucosidase
  • specific for alpha 1,4
  • starts at non-reducing end
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6
Q

characteristics of sucrase-isomaltase complex

A
  • most of the intestines ability to hydrolyze alpha 1,6
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7
Q

characteristics of trehalase

A
  • breaks down alpha 1,1 bonds
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8
Q

characteristics of beta- glycosidase

A
  • breaks beta 1,4 bonds between galactose and glucose
  • lactose site
  • active in young children
  • susceptible to injury
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9
Q

pepsinogen activation

A
  • low pH (high H concentration)
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10
Q

trypsinogen activation

A
  • enteropeptidase
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11
Q

chymotrypsinogen activation

A
  • trypsin
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12
Q

proelastase activation

A
  • trypsin
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13
Q

procarboxypeptidase activation

A
  • trypsin
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14
Q

function of colipase

A
  • binds to fat and lipase activating pancreatic lipase
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15
Q

ApoE

A
  • recognized by liver cells

- digestion by lysosomes

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16
Q

ApoCII

A
  • activates lipoprotein lipase

- digestion of TGs in muscle and adipose

17
Q

vitamin B12

A
  • requires binding parters such as IF

- absorbed in the ileum by transcobolamin

18
Q

sources and absorption of iron

A
  • heme - from red meats, nonheme from plants
  • absorbed in duodenum and jejunum
  • transferrin binds for transport and ferritin binds for storage
19
Q

absorption of calcium

A
  • duodenum absorption regulated by vitamin D and parathyroid hormone
20
Q

absorption of sodium

A
  • over 50% absorbed in jejunum

- absorbed by cotransporters

21
Q

absorption of bicarbonate

A
  • reabsorbed in duodenum and jejunum

- Cl/HCO3 exchanger

22
Q

complication of cystic fibrosis

A
  • blocked pancreatic duct resulting in decreased secretion of pancreatic enzymes
  • malabsorption
  • treat with pancreatic enzymes
23
Q

gallstones

A
  • precipitated bilirubin
  • fats are not digested
  • deficiencies of fat soluble vitamins
24
Q

abetalipoproteinemia

A
  • lack of microsomal triglyceride transfer protein (MTP)
  • limited synthesis of chylomicrons (ApoB-48) or VLDL (ApoB-100)
  • steatorrhea, caloric and vitamin deficiencies
25
Q

Hartnup’s disease

A
  • absence of neutral amino acid transporter
  • high levels of amino acid in urine
  • niacin deficiencies
  • di and tri peptide absorption can compensate