hypothalamic drugs Flashcards
what are types of GnRH
Goserelin
Leuprolide
Nafarelin
Histrelin
what is the role of GNRH agonists
Excessive pituitary stimulation → ↓ GnRH receptors → ↓ LH and FSH secretion → ↓ estradiol production in ovaries, ↓ testosterone in male individuals
what are indications for GnRH agonists
breast cancer
prostate
Endometriosis
Precocious puberty
what are side effects of gnrh agonists
Vaginal dryness
Hot flashes
Nausea, vomiting
Decreased bone mineral density
what is the moa of GnRH antagonists
Block GnRH receptors on pituitary to decrease FSH and LH secretion
what are the indications of gnRH
Prostate cancer
In vitro fertilization
what is the moa of Somatostatin analogs
Inhibit GH secretion
Inhibit the release of hormones (e.g., gastrin, glucagon, insulin, )
what is the indication for somatostatin analogs
Acromegaly
what are the side effects of somatostatin analogs
Fatigue, weakness
Depressed mood
Gastrointestinal
Steatorrhea
Nausea, vomiting
what is the moa of oxytoxin
Mediates calcium influx → uterine contraction
what are types of adh analogs
Desmopressin
Terlipressin
