Hypohalamic and Pituitary Hirmones

Question 1

Aquaporun 123 =
Aquaporin 4 =
5=

Answer 1

Kidney
Brain
Salivary, lacrimal gland and respiratory tract

Question 2

Nephrogenic Diabetes insipidus is caused due to?

Answer 2

Inability of kidneys to respond to ADH
Congenital defect in V2 receptor , due to gene mutations.

Question 3

Nephrogenic DI is a ———- trait

Answer 3

X linked trait

Question 4

Fsh ,lh ,tsh and cG are ……

Answer 4

Glycoprotein hormones of ab heterodimeric structure

Question 5

achain is identical in all the ab heterodimeric structure glycoprotein but the …….. Is distinct and gives hormones their uniqueness

Answer 5

B chain

Question 6

The GH gene is GH1 and it is …….. Of a cluster of 5 genes on the long arm of chromosome 17( q22,24)

Answer 6

1st
The other genes are CS1 CS2 GH2 CSP they have >90 % sequence identity with GH1

Question 7

Autosomal dominant iGHD occurs at splice site of …….

Answer 7

Intron 3
This leads to the overproduction of a 20 kd protein that lacks aa normally encoded by exon 3.