Hemoglobin RS Flashcards
The heme pocket of what polypeptide chain is large enough to occupy the O2?
Alpha chain
The heme pocket of the beta chain is blocked by?
Valine residue
At what carbon position of heme does it bond with the Arginine and lysine of the polypeptide chain?
List in respective order
Carbon 6- Arginine
Carbon 7- lysine
The polypeptide chain of globin contains numerous amino acids such as?
Histidine
Isoleucine
Lysine
The 5th linkage of Fe ( internal linkage) is between the Fe and …………. Ring of histidine in the polypeptide chain
Imidazole ring
Hb A3 is an altered form of HbA discuss
Hb A3 is an electrophoretically fast fraction of HbA.
It is found in old RBCs.
Amounts3-10%
HbA1c is a form of the glycosylated form of Hb A discuss
It is found in a ℅3-5 % of total Hb
It can increase to up to 6-15% in Patients with diabetes mellitus