Hemoglobin RS Flashcards

1
Q

The heme pocket of what polypeptide chain is large enough to occupy the O2?

A

Alpha chain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The heme pocket of the beta chain is blocked by?

A

Valine residue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

At what carbon position of heme does it bond with the Arginine and lysine of the polypeptide chain?
List in respective order

A

Carbon 6- Arginine
Carbon 7- lysine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

The polypeptide chain of globin contains numerous amino acids such as?

A

Histidine
Isoleucine
Lysine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

The 5th linkage of Fe ( internal linkage) is between the Fe and …………. Ring of histidine in the polypeptide chain

A

Imidazole ring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Hb A3 is an altered form of HbA discuss

A

Hb A3 is an electrophoretically fast fraction of HbA.
It is found in old RBCs.
Amounts3-10%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

HbA1c is a form of the glycosylated form of Hb A discuss

A

It is found in a ℅3-5 % of total Hb
It can increase to up to 6-15% in Patients with diabetes mellitus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly