Hypertension Flashcards
defintion
SBP>140mmHg
DBP>90mmHg
primary hypertension
unkown cause
secondary hypertension
phenochromocytome - tumour on adrenal gland
renal artery stenosis
Blood pressure
the pressure exerted on teh arterial walls during systole and diastole
rate presure product - HRxSV
measuring arterial BP
place cuff on arm
will not be able to hear anthing
increase cuff pressure to 160
slowly release pressure, note when you can start hearing tapping sound
continue decreasing pressure until tapping sound cant no longer be heard
effect on the population
all cause death - 9.4mil/year
no 1 physiloigical cause of global mortaility
prevalance
874 million adults worldwide are hypertensive
pre-hypertension
120-140mmHg
prevent hypertension occuring
as you get about 120, the risk increases quickly as a sliding scale
risk of a heart attack depending on BP
if you are hypertensive you are 7.4x more likely to have a MI
risk factors - unmodifiable
family history
age
sex
ethnicity
risk factors - modifiable
PA diet weight smoking sleep alcohol stress
repsonse to high BP
increase in VR, increase stretch on right atria through baroreceptors
bainbridge reflex - increase VR = increase HR
increase ANP release by atria
increase BNP
act on kidenys
increase Na+ excretion - increase water excretion
increase GFR
act on hypothalumus to decrease thrist
increase vasodilation via increase smooth muscle cGMP
decrease sympathetic tone
responce to low BP
decrease VR - no firing of baroreceptors
decrease ANP & BNP
afferent and efferent arteroile in JGA detect decrease
release renin
- convert angiotensinogen to angiotension I
- angiotension I to angiotension II via ACE
- increase vasoconstriction
- increases sypathetic activity
- decrease Na+ excretion via aldosterone from adrenal gland
- increase ADH (pituartry gland) - increase collecting duct absorption
increase thirst
= increase water absorption + increased BP
pharamalogical interventions
reduce BP
- ACE inhibitors
beta blockers - slow HR
diurectics
BP equation
QxTR=BP