Hypersomnias

Question 1

Type II Narcolepsy Diagnostic Criteria
PSG and MSLT criteria

Answer 1

PSG: 6 hours of total sleep time
MSLT:
SL < 8 minutes, 2 SOREMS, or 1 SOREM if previous PSG showed 15 minute SOREM
NO CATAPLEXY

Question 2

Criteria for Idiopathic Hypersomnia

Answer 2

EDS lasting 3 months or more
No Cataplexy
No more than 1 SOREM on PSG/MSLT

AND 1/3 of these:

• MSLT with mean SL < 8 minutes
• 11 hours of sleep on PSG
• actigraphy with average 11 hours of sleep in 1 week

Question 3

Cause of Type 1 Narcolepsy

HLA???

Answer 3

Loss of hypocretin neurons in hypothalamus

HLA DQB10602 +

Question 4

Side Effects of Modafinil

Answer 4

Makes birth control not work
headaches
anxiety
SJS

Question 5

EEG characteristics of Fatal Familial Insomnia

Answer 5

Loss of spindles

Question 6

Kids with type 1 narcolepsy have a 10x chance of what physical exam finding?

Answer 6

Precocious puberty

Question 7

What is seen on EEG in people with Klein Levin Syndrome

Answer 7

generalized slowing

Question 8

idiopathic hypersomnia has a higher percentage of what sleep stage

Answer 8

n3

Question 9

What part of the brain is affected in fatal familial insomnia

Answer 9

mediodorsal thalamus

Question 10

Klein Levin Symptoms

Answer 10

Hyperphagia, hypersomnia, hypersexuality, cognitive issues
Male predominant

Question 11

Klein Levin Diagnostic Criteria

Answer 11

At least 2 recurrent episodes lasting 2 days to 5 weeks
Episodes recur yearly or at least once every 18 months
Normal function between episodes
Must have hypersomnia and…
- cognitive dysfunction
- hyperphagia
- hypersexuality

Question 12

Catathrenia is more common in what slee stage?

Answer 12

REM