Circadian Rhythm

Question 1

When is the typical core body min temp

Answer 1

2-3 hours before habitual wake up time

Question 2

Features of irregular sleep wake disorder
- how many bouts of sleep and for how long?
- what is the best therapy

Answer 2

At least 3 bouts of sleep lasting 1-4 hours
Best therapy is light in AM

Question 3

When traveling east, the circadian clock needs to phase ___

Answer 3

Advance

Question 4

When traveling west, the circadian clock needs to phase ___

Answer 4

Delay

Question 5

When traveling East from US to Europe, when should you avoid light?

Answer 5

Avoid light in AM Europe time, seek out light in PM Europe time
If you are exposed to light before you natural T-min, you will phase delay (you want to phase advance when traveling east)

Question 6

How do you pre-travel phase shift when traveling East?

Answer 6

You need to phase advance
3 days prior to trip you can phase advance by
- going to bed earlier each day
- waking up earlier each day
- AM light
- melatonin 2 hours before sleep

Question 7

Treatment of advanced sleep wake phase disorder?

Answer 7

Bright light in evening

Question 8

How do you treat delayed phase circadian rhythm disorder?

Answer 8

melatonin 4-5 hours before their habitual sleep time
Bright light exposure after habitual Tmin
- the habitual Tmin is 2 hours before their normal wake up time
As you phase advance these timings have to be adjusted

Question 9

Gene associated with delayed sleep wake circadian rhythm

Answer 9

PER3

Question 10

Type of cancer associated with shift work

Answer 10

Breast cancer

Question 11

Gene associated with Advanced Circadian Rhythm Disorder

Answer 11

Per2

Question 12

Daylight savings in the spring is associated with developing what condition

Answer 12

Afib