Effect of Drugs on Sleep Flashcards
Alcohol
- sleep architecture
- REM and REM latency
- OSA?
Decreased sleep latency
Increased sleep disruption
Decreased REM
Increased apneas
Anticonvulsants
Increase sleepiness
Increase SWS
Decrease REM
Antidepressants
- REM and REM latency
- how does it affect RLS and RBD
Suppress REM and prolong REM latency
REM rebound may occur after withdrawal
Increased RLS and RBD
Antihistamines
Increased sedation but do not affect architecture
Clonidine
Increase slow wave sleep
Antipsychotics
- which medication is the exception?
Sedation
Increased SWS except quetiapine
Nicotine
Reduce SWS
Opiates
Reduce REM
Benzos
Reduce REM and SWS
Barbiturates
Reduce REM
MAOs
Most effective at eliminating REM
What part of the receptor do non benzodiazepines affect
Type 1 GABAa receptor
Caffeine
Reduces SWS, no effect on REM
Beta blockers effect on sleep
reduce melatonin production
How do Amphetamines work
Increase dopamine and norepi
Dopaminergic Agonists side effects
Nausea, fatigue, hypersomnia, impulsive behavior, Augmentation
RLS treatment (1st, 2nd, 3rd line)
Dopaminergic agonists, then gabapentin, then opiates
Ropinirole main side effect
Hypotension
Donepezil
Increase in REM, decrease SWS
Nefazodone
Increase REM
Increase SWS
THC
Decrease REM
Discontinuation of what medication can induce “Status Cataplexicus”
Anti depressants
Gabapentin
Increase SWS and REM
Steroids
Decrease REM
