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Immunology Shelf > Hypersensitivity Reactions > Flashcards

Hypersensitivity Reactions Flashcards

1
Q

Type I

A

IgE
Allergens
Increased eosinophils

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2
Q

Type II

A

IgG
Insoluble
Immune cytolysis (cell destruction mediated by an antibody that activates complement)

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3
Q

Type III

A

IgG
Soluble
Immune complex deposition in joints ad kidneys is common

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4
Q

Type IV

A

Th1 cell mediated
Soluble and Insoluble
Contact dermatitis

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5
Q

allergic rhinitis

A

Type I

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6
Q

asthma

A

Type I

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7
Q

systemic anaphylaxis

A

type I

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8
Q

drug allergies (penicillin)

A

type II

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9
Q

chronic urticaria (antibody to FceRI

A

type II

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10
Q

serum sickness

A

type III

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11
Q

arthus reaction

A

type III

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12
Q

contact dermatitis

A

type IV

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13
Q

chronic asthma/chronic allergic rhinitis

A

type IV

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14
Q

tuberculin reaction

A

type IV

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15
Q

mast-cell activation

A

Type I

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16
Q

complement, FcR+ cells (phagocytosis, NK cells)

A

Type II

17
Q

Antibody alters signaling

A

Type II

18
Q

complement and phagocytes

A

Type III

19
Q

macrophage activation

A

Type IV (Th1 cells)

20
Q

eosinophil activation

A

Type IV (Th2 cells)

21
Q

cytotoxicity

A

Type IV (CTL)

22
Q

Delayed-type hypersensitivity

A

(Type IV) antigen: insect venom, mycobacterial proteins

local skin swelling, erythema, induration, cellular infiltrate, dermatitis

23
Q

Contact hypersensitivity

A

(type IV) antigen: haptens, poison ivy (pentadecacatechol, DNFB, metal, chromate
erythema, cellular infiltrate, vesicles, intraepidermal abscesses

24
Q

gluten-sensitive enteropathy (Celiac’s disease)

A

(type IV) gliadin

villous atrophy in small bowl and malabsorption

25
Q

Factors that influence autoimmune diseases

A
  1. HLA genotype
  2. Microbial infections: adjuvant effects and molecular mimicry
  3. Infection/Inflammation: induction of MHC molecules
  4. Injury (exposs auto-antigens in immune privileged organs)
  5. Gender

Immunology Shelf (15 decks)

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