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Immunology Shelf > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-1

A

induces fever, induced release of acute phase proteins
from: phagocytes, lymphocytes, endothelial cells
targets: lymphocytes, macrophages, endothelium
activates cells, increases adhesion molecule expression

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2
Q

IL-2

A

source and target are T cells
signs of T cell activation specific to certain antigens
induces T cell proliferation
activates T cells

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3
Q

IL-3

A

targets hematopoietic stem and progenitor cells
from T cells
induces growth and differentiation of progenitor cells such as macrophage progenitors

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4
Q

IL-4

A

induces TH2 polarization
from Th2 cells, mast cells, macrophages
targets T and B cells, eosinophils, mast cells
B cell growth, IgE and IgG1 isotype selection
eosinophil and mast cell activation
suppresses CMI

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5
Q

IL-5

A 
targets B cells and eosinophils
IGA isotype selection
from Th2 cells, mast cells
induces B cell growth and differentiation
eosinophil activation
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6
Q

IL-6

A

from Th2 cells, B cells, macrophages, fibroblasts, endothelial cells
targets B cells, hepatocytes
induced B cell differentiation, production of acute phase proteins, fever

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7
Q

IL-8 (CXCL8)

A

chemokine that targets neutrophils
from macrophages, endothelial cells, fibroblasts
targets basophils, T cells
chemotatic and angiogenic

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8
Q

IL-10

A 
inhibits cytokine synthesis
suppresses cell mediated immunity
from activated T cells, macrophages
targets Th1 cells
promotes B cell proliferation
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9
Q

IL-12

A 
induces Th1 polarization, suppresses Th2 activation
from B cells, macrophages, DCs
targets T cells, NK cells
activates CD8 T and NK cells
promotes CMI
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10
Q

IL-13

A

from Th2 cells
targets macrophages, B cells
induces B cell growth and differentiation
inhibits production of pro-inflammatory cytokines

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11
Q

IL-15

A

from macrophages, T cells
targets T cells, activated B cells
actions similar to IL-2

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12
Q

IL-18 (IFN gamma-inducing factor)

A

from phagocytes
target T cells
induced production of IFN gamma, IL2 and GM-CSF

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13
Q

TNF-alpha

A 
targets and effects similar to IL-1 plus induced MHC class I protein expression, tumor necrosis, and stimulates angiogenesis
from macrophages, mast cells, lymphocytes, endothelial cells
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14
Q

TNF-beta (lymphotoxin A)

A

from lymphocytes

targets and effect similar to TNF-alpha except not associated with inducing shock

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15
Q

IFN-alpha

A

targets tissue cells
induces antiviral state, MHC class I protein and stimulates NK cells, production of IL-12 and TH1 cells
from lymphocytes, macrophages, epithelial cells

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16
Q

IFN-beta

A

induces anti-viral state, MHC class I expression
from fibroblasts, epithelial cells
targets tissue cells, leukocytes

17
Q

IFN-gamma

A

induces expression of MHC class I and II
from T cells, NK cells
targets leukocytes tissue cells, TH2 cells
activates phagocytes, inhibits TH2 cells, enhances leukocyte-endothelial adherence
induces IgG2a class switching

18
Q

M-CSF

A

targets monocytes and monocyte progenitors
from macrophages, fibroblasts, and endothelial cells
induces proliferation of monocyte precursors

19
Q

G-CSF

A

target granulocyte precursors
from macrophages, fibroblasts and endothelial cells
induces proliferation of precursors to mature granulocytes

20
Q

GM-CSF

A

targets granulocyte/macrophage progenitors
from T cells, macrophages, fibroblasts and endothelial cells
promotes the differentiation of precursors, stimulates neutrophils, eosinophils and macrophages

21
Q

MCP-1 (chemokine)

A

from macrophages, fibroblasts, epithelial and endothelial cells
targets monocytes, basophils, mast cells
chemotactic agent for monocytes, induces histamine release by mast cells and basophils

22
Q

TGF-alpha

A

from macrophages and other cells
targets fibroblasts, epithelial and endothelial cells
stimulates fibroblast growth and angiogenesis

23
Q

TGF-beta

A

induces B cell isotype switching to IgA with IL-5
suppression of immune response
from TH2/CD4, B cells, platelets, macrophages and mast cells
inhibits proliferation of immune cells
induces IL-1 production by macrophages

24
Q

Hematopoietic cytokines

A

G-CSF, GM-CSF, M-CSF, IL-3, IL-5, EPO, TPO

25
Q

Suppressive cytokines

A

IL-10

TGF-beta

26
Q

TH1 cytokines produce

A

IFN-gamma
IL-2
TNF-beta

27
Q

TH2 cytokines produce

A

IL-4, IL-5, IL-6, IL-10, IL-13

28
Q

Endothelial activating cytokines

A

IL-1, IFN-gamma

29
Q

inflammatory cytokines

A

IL-1beta, TNF-alpha, IL-6, CXCL8, IL-12

30
Q

Anti-viral cytokines

A

IFN-alpha
IFN-beta
IFN-gamma

Immunology Shelf (15 decks)

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