Autoimmune diseases Flashcards
Autoimmune hemolytic anemia
(type II) autoantigen: Rh blood group antigens, I antigen
destruction of RBCs by complement and phagocytes, anemia (similar to drug induced HA)
Autoimmune thrombocytopenia purpura
(type II) autoantigen: platelet integrin gpIIb:IIIa
abnormal bleeding
Goodpasture’s syndrome
(type II) autoantigen: Non-collagenous domain of basement membrane collagen type IV
glomerulonephritis, pulmonary hemorrhage
Pemphigus vulgaris
(type II) autoantigen: epidermal cadherin
blistering of skin
Acute rheumatic fever
(type II) autoantigen: streptococal cell wall antigens (Abs cross react with cardiac muscle)
arthritis, myocarditis, late scarring of heart valves
Graves’ disease
(type II) autoantigen: thyroid-stimulating hormone receptor
hyperthyroidism
Myasthenia gravis
(type II) autoantigen: acetylcholine receptor
progressive weakness
Insulin-resistant diabetes
(type II) autoantigen: insulin receptor antagonist
hyperglycemia, ketoacidosis
Hypoglycemia
(type II) autoantigen: insulin receptor agonist
hypoglycemia
Subactute bacterial endocarditis
(type III) autoantigen: bacterial antigen
glomerulonephritis
Mixed essential cryoglobullinemia
(type III) autoantigen: rheumatoid factor IgG complexes
systemic vasculitis
Systemic lupus erythematosus
(type III) autoantigen: DNA, histones, ribosomes, snRNP, scRNP
glomerulonephritis, vasculitis, arthritis (soluble Ag-Ab complex)
Insulin-dependent diabetes mellitus
(type IV) autoantigen: pancreatic beta-cell antigen
beta-cell destruction (CD4 and CD8 T cells)
Rheumatoid arthritis
(type IV) autoantigen: unknown synovial joint antigen
joint inflammation and destruction
IgM/G rheumatic factor to IgG-Fc (diagnosis and immune complex formation)
Multiple sclerosis
(type IV) autoantigen: myelin basic protein, proteolipid protein
brain degeneration, paralysis (demyelination of CNS)
Local skin Arthus reaction following injection of a drug that induces antibodies and forms Ag-Ab immune complexes
Type III
Group A strep
rheumatic fever
Campylobacter jejuni
Guillain-Barre
Borrelia Burgdorferi
HLA-DR2, DR4
Lyme Disease
Chlamydia
HLA-B27
Reiter’s syndrome
Group A hemolytic streptococcus
Goodpasture’s syndrome
Chronic thyroiditis (Hashimoto’s)
(Type II and IV) autoantigen: antithyrobglobulin and antithyroid peroxidase)
goiter, hypothyroidism
Coxsackie A virus
Coxsackie B virus
echoviruses
rubella
HLA-DQ2, HLA-DQ8, DR4
Type 1 Diabetes
Acute Disseminated Encephalomyelitis
(type IV) autoantigen: MBP and other myelin antigens
follows infection of vaccination
Acute Inflammatory Polyneuropathy (Guillain Barre)
(type II and IV) autoantigen: to periheral nerve antigens
demyelination of peripheral nerves
Anti-cardiolipin, lupus anticoagulant
SLE, antiphospholipid syndrome
Anti-centromere
Limited scleroderma (CREST) syndrome
Anti-desmoglein
Pemphigus vulgaris
Anti-glutamate decarboxylase
Type 1 diabetes mellitus
Anti-hemidesmosome
bullous pemphigoid
Antihistone
drug-induced lupus
Anti-smooth muscle
autoimmune hepatitis
Anti-SSA, anti-SSB
Sjogren syndrome
IgA antiendomysial, IgA ant-tissue transglutaminase
Celiac disease
