Hypersensitivity Reactions Flashcards
Match the following types of hypersensitivity with their
respective type of reaction.
1. ______ Type I hypersensitivity
2. ______ Type II hypersensitivity
3. ______ Type III hypersensitivity
4. ______ Type IV hypersensitivity
a. Cytotoxic reaction
b. Cell-mediated reaction
c. Immune complex reaction
d. Anaphylactic reaction
- d
- a
- c
- b
With which cell type are anaphylactic reactions
associated?
a. T lymphocyte
b. B lymphocyte
c. Monocyte
d. Mast
d. Mast
Type III reactions are exemplified by all the following
except:
a. Arthus reaction
b. Serum sickness
c. Glomerulonephritis
d. Shingles
d. Shingles
Type IV reactions are responsible for all the following
except:
a. Contact sensitivity
b. Delayed hypersensitivity
c. Elimination of tumor cells bearing neoantigens
d. Hemolysis of red blood cells
d. Hemolysis of red blood cells
Type I hypersensitivity reactions can be associated with:
a. Food allergies
b. Hay fever
c. Asthma
d. All of the above
d. All of the above
The most common agents that cause anaphylactic
reactions are:
a. Drugs and food
b. Drugs and insect stings
c. Poison ivy and insect stings
d. Food and insect stings
b. Drugs and insect stings
Arrange the sequence of events in anaphylaxis in the
proper sequence.
10. ________
11. ________
12. ________
a. The effects of mediator release produce vascular
changes, activation of platelets, eosinophils, and
neutrophils, and activation of the coagulation
cascade.
b. The offending antigen attaches to the IgE antibody fixed
to the surface membrane of mast cells and basophils.
c. Activated mast cells and basophils release various
mediators.
- b
- c
- a
13-18. Complete the table, choosing from the possible
answers provided.
Mediators of Anaphylaxis
Mediator Primary Action
Histamine 13. ________
Leukotrienes 14. ________
Serotonin 15. ________
Platelet-activating factor 16. ________
Eosinophil chemotactic factors
of anaphylaxis 17. ________
Prostaglandins 18. ________
Possible answers to questions 13-15:
a. Enhances the effects of
histamine on target organs
b. Increases vascular
permeability and
promotes contraction
of smooth muscle
c. Generates kinins
d. Contracts smooth
muscle
Possible answersto questions 16-18:
a. Affects smooth muscle tone
and vascular permeability
b. Enhances the release of
histamine and serotonin
c. Attracts cells to area of
activity; these cells release
secondary mediators that
may limit the effects of
primary mediators.
d. Alters bronchial smooth
muscle
- b
- a
- d
- b
- c
- a
In vitro evaluation of type I hypersensitivity reactions can
include:
a. RIST
b. Skin testing
c. Neither a nor b
d. Both a and b
a. RIST
Cytotoxic reactions are characterized by the interaction of:
a. IgG to soluble antigen
b. IgG to cell-bound antigen
c. IgM to soluble antigen
d. IgM or IgG to cell-bound antigen
d. IgM or IgG to cell-bound antigen
An example of a delayed nonhemolytic (type II
hypersensitivity) reaction is:
a. Febrile reaction
b. Graft-versus-host disease
c. Urticaria
d. Congestive heart failure
b. Graft-versus-host disease
Under normal conditions, immune complexes protect the
host because they:
a. Facilitate the clearance of various antigens
b. Facilitate the clearance of invading microorganisms
c. Interact with complement
d. Both a and b
d. Both a and b
Immune complexes can:
a. Suppress or augment the immune response by
interacting with T and B cells
b. Inhibit tumor cell destruction
c. Be deposited in blood vessel walls
d. All of the above
d. All of the above
The general anatomic sites of antigen-antibody
interaction are:
a. Tissues with a large filtration area
b. Interstitial fluids
c. Cell surface membranes or fixed intercellular
structures
d. All of the above
d. All of the above
Type IV hypersensitivity reactions are responsible for all
the following except:
a. Contact sensitivity
b. Elimination of tumor cells
c. Rejection of foreign tissue grafts
d. Serum sickness
d. Serum sickness
