Infectious Mononucleosis

Question 1

The Epstein-Barr virus can cause all the following except:
a. Infectious mononucleosis
b. Burkitt’s lymphoma
c. Nasopharyngeal carcinoma
d. Neoplasms of the bone marrow

Answer 1

d. Neoplasms of the bone marrow

Question 2

The primary mode of EBV transmission is:
a. Exposure to blood
b. Exposure to oral-pharyngeal secretions
c. Congenital transmission
d. Fecal contamination of drinking water

Answer 2

b. Exposure to oral-pharyngeal secretions

Question 3

Infants infected with EBV are more likely to experience
symptomatic infection than EBV-infected adolescents.
a. True
b. False

Answer 3

b. False

Question 4

IgM heterophile antibody is characterized by all the
following features except:
a. Reacts with horse, ox, and sheep RBCs
b. Absorbed by beef erythrocytes
c. Absorbed by guinea pig kidney cells
d. Does not react with EBV-specific antigens

Answer 4

c. Absorbed by guinea pig kidney cells

Question 5

Characteristics of EBV-infected lymphocytes include all
the following except:
a. B type
b. Expression of viral capsid antigen
c. Expression of early antigen
d. Expression of EBV genome

Answer 5

d. Expression of EBV genome

Question 6

Which of the following stages of infectious mononucleo-
sis infection is characterized by antibody to Epstein-Barr
nuclear antigen (EBNA)?
a. Recent (acute) infection
b. Past infection (convalescent) period
c. Reactivation of latent infection
d. Both b and c

Answer 6

d. Both b and c

Question 7

Which of the following stages of infectious mononucleosis
infection is (are) characterized by heterophile antibody?
a. Recent (acute) infection
b. Past infection (convalescent) period
c. Reactivation of latent infection
d. Both a and c

Answer 7

d. Both a and c

Question 8

What percentage of the world’s population is exposed to
EBV?
a. 25%
b. 50%
c. 75%
d. 95%

Answer 8

d. 95%

Question 9

Infectious mononucleosis postperfusion syndrome is a
primary infection resulting from a blood transfusion from
a(n) _______ to a(n) _______ recipient.
a. Immune; nonimmune
b. Nonimmune; immune
c. Infected; nonimmune
d. Infected; immune

Answer 9

a. Immune; nonimmune

Question 10

In infectious mononucleosis, there is no:
a. Acute state
b. Latent state
c. Carrier state
d. Reactivation

Answer 10

c. Carrier state

Question 11

The incubation period of infectious mononucleosis is:
a. 2 to 4 days
b. 10 to 15 days
c. 10 to 50 days
d. 51 to 90 days

Answer 11

c. 10 to 50 days

Question 12

The use of horse erythrocytes in rapid slide tests for
infectious mononucleosis increases their:
a. Cost
b. Sensitivity
c. Specificity
d. Both b and c

Answer 12

d. Both b and c

Question 13

EBV-infected B lymphocytes express all the following
new antigens except:
a. Viral capsid antigen VCA
b. Early antigen EA
c. Cytoplasmic antigen (CA)
d. Nuclear antigen NA

Answer 13

c. Cytoplasmic antigen (CA

Question 14

Anti-EBNA IgG does not appear until a patient has
entered the:
a. Initial phase of infection
b. Primary infection phase
c. Convalescent period
d. Reactivation of infectious stage

Answer 14

c. Convalescent period

Question 15

Match each procedure to the appropriate description.
15. _______ Paul-Bunnell screening test
16. _______ Davidsohn differential test
17. _______ MonoSlide agglutination test
a. Distinguishes between heterophile antibodies; uses
beef erythrocytes, guinea pig kidney cells, and sheep
erythrocytes
b. Detects heterophile antibodies and uses horse
erythrocytes
c. Detects heterophile antibodies and uses sheep
erythrocytes

Answer 15

15. c
16. a
17. b