Acquired Immunodeficiency Syndrome Flashcards
The major structural protein (core) of the HIV-1 virus is:
a. gp41
b. p24
c. gp34
d. gp140
b. p24
The infectious process of AIDS begins when the gp120
protein on the viral envelope bends to the protein
receptor, _______, on the surface of a target cell.
a. CD8
b. CD4
c. p24
d. p26
b. CD4
HIV can infect all of the following cells except:
a. CD4+ subset of lymphocytes
b. Macrophages
c. Monocytes
d. Polymorphonuclear leukocytes
d. Polymorphonuclear leukocytes
The most rapidly growing segment of the HIV-infected
population is:
a. Homosexual males
b. Lesbians
c. Health care workers
d. IV drug users and their sexual partners
d. IV drug users and their sexual partners
In HIV infections, a window period of seronegativity
extends from the time of initial infection up to:
a. 2 weeks
b. 2 to 6 weeks or longer
c. 6 to 12 weeks or longer
d. 4 to 8 months or longer
c. 6 to 12 weeks or longer
HIV antibodies are usually detected by (6)
___________ and confirmed by (7) ___________.
Possible answers for question 6:
a. Latex agglutination
b. Enzyme immunoassay
c. Enzyme inhibition
d. Radioimmunoassay
Possible answers for question 7:
a. Southern blot
b. Northern blot
c. Western blot
d. DNA hybridization
- b
- c
The AIDS-causing virus HIV has also been referred to as:
a. Human T-lymphotropic virus type III
b. HTLV-III
c. Lymphadenopathy-associated virus (LAV )
d. All of the above
d. All of the above
HTLV-III was unique when it was isolated because it:
a. Is a bovine infectious retrovirus
b. Is a canine infectious retrovirus
c. Was identified as the cause of AIDS
d. Is a DNA containing virus
c. Was identified as the cause of AIDS
Fill in the blanks in the following table with the
correct letter, choosing from the following answers:
a. Codes for p24 and for proteins such as p17, p9, and
p7
b. Codes for two glycoproteins, gp41 and gp120
c. Produces DNA polymerase; produces endonuclease
Viral Genome Structural Components
Component Product
pol 10. _______
gag 11. _______
env 12. _______
- c
- a
- b
Arrange the HIV-1 life cycle events in proper order.
13. _______ a. Reverse transcriptase converts viral
RNA into proviral DNA.
14. _______ b. New virus particles are produced as the result of normal cellular activities of
transcription and translation.
15. _______ c. New particles bud from the cell membrane.
16. _______ d. Virus attaches to CD4 membrane
receptor and sheds its protein coat,
exposing its RNA core.
17. _______ e. Proviral DNA is integrated into the
genome (genetic complement of cell).
- d
- a
- e
- b
- c
The criteria for HIV infection for persons 13 years of age
or older include:
a. Repeatedly reactive screening test for HIV antibody
b. Specific HIV antibody identified by use of supple-
mental tests
c. Direct identification of the virus
d. All of the above
d. All of the above
After the early period of primary HIV infection, the
patient enters a period of clinical latency that lasts a
median of _______ years.
a. 5
b. 10
c. 15
d. 20
b. 10
As AIDS progresses, the quantity of _______ diminishes
and the risk of opportunistic infection increases.
a. HIV antigen
b. HIV antibody
c. CD4+ T lymphocytes
d. CD8+ T lymphocytes
c. CD4+ T lymphocyte
The clinical symptoms of the later phase of AIDS are:
a. Weight loss and decreased polymorphonuclear
leukocyte (PMN) cells
b. Extreme weight loss and fever
c. Multiple secondary (opportunistic) infections
d. Both b and c
d. Both b and c
The most frequent malignancy observed in AIDS
patients is:
a. Pneumocystis jiroveci (P. carinii)
b. Kaposi’s sarcoma
c. Toxoplasmosis
d. Non-Hodgkin’s lymphoma
b. Kaposi’s sarcoma
