Cytomegalovirus

Question 1

All the following describe CMV except:
a. Herpes family virus
b. DNA virus
c. Cell-associated virus
d. Epidemic worldwide

Answer 1

d. Epidemic worldwide

Question 2

Because CMV can persist latently, an active infection
may develop as a result of all the following conditions
except:
a. Pregnancy
b. Immunosuppressive therapy
c. Organ or bone marrow transplantation
d. Transfusion of leukocyte-poor blood

Answer 2

d. Transfusion of leukocyte-poor blood

Question 3

CMV is recognized as the cause of congenital viral
infection in what percentage of all live births?
a. 0.1% to 0.4%
b. 0.4 to 2.5%
c. 2.5% to 4.9%
d. 4.9% to 9.9%

Answer 3

b. 0.4 to 2.5%

Question 4

Transfusion-acquired CMV infection can cause:
a. Mononucleosis-like syndrome
b. Hepatitis
c. Rejection of a transplanted organ
d. All of the above

Answer 4

d. All of the above

Question 5

Match the three types of CMV infection with their
appropriate description.
5. ______ Primary infection
6. ______ Reactivated infection
7. ______ Reinfection
a. Significant antibody response and viral shedding are
caused by different strain of virus.
b. Seronegative recipient is transfused with blood from
actively or latently infected donor.
c. Seropositive recipient is transfused with blood from
a CMV antibody–positive or –negative donor.

Answer 5

5. b
6. c
7. a

Question 6

Match the following serologic markers of CMV
infection:
8. ______ Early antigens
9. ______ Immediate-early antigens
10. ______ Late antigens
a. Appear 72 hours after infection or at the end of the
viral replication cycle
b. Appear within 1 hour of cellular infection
c. Present within 24 hours

Answer 6

8. c
9. b
10. a

Question 7

Antibodies to immediate-early and early antigens are
associated with:
a. Primary active infection
b. Reactivated active infection
c. Latent infection
d. Either a or b

Answer 7

b. Reactivated active infection

Question 8

Match the following:
12. ______ Primary infection
13. ______ Reactivation of latent infection in seropositive
IgG patient
14. ______ Reinfection with strain of CMV different from
original strain
a. IgG, but IgM response unknown
b. Specific IgM antibody response
c. IgG (no detectable IgM)

Answer 8

12. b
13. c
14. a

Question 9

All the herpesviruses share the feature of being:
a. RNA viruses
b. Small viruses
c. Cell-associated viruses
d. Nonenveloped viruses

Answer 9

c. Cell-associated viruses

Question 10

A most likely mode of CMV acquisition is:
a. Irradiated blood products
b. Non-irradiated blood transfusions containing viable
leukocytes
c. Venereal route
d. All of the above

Answer 10

b. Non-irradiated blood transfusions containing viable
leukocytes

Question 11

Which of the following appears to be the only immuno-
suppressed group at significant risk of acquiring CMV
infection?
a. Transplant patients
b. Seronegative patients
c. Seropositive patients
d. Health care workers

Answer 11

b. Seronegative patients

Question 12

All the following are methods for the prevention of
CMV except:
a. Irradiated blood products
b. Leukocyte-depleted blood products
c. Immune globulin with CMV antibodies
d. Transfusion of fresh blood

Answer 12

d. Transfusion of fresh blood

Question 13

Indicate true statements with the letter A and false
statements with the letter B.
19. ______ Primary and recurrent maternal CMV infections
can be transmitted in utero.
20. ______ CMV is the most common intrauterine
infection.
21. ______ Few CMV-infected newborns are asymptomatic.
22. ______ Normal adults and children usually experience
CMV infection without serious complications.

Answer 13

19. a
20. a
21. b
22. a