hypersensitivity disorder - type 3 Flashcards
what is type 3 hypersensitivity reaction
IgG or IgM
Immune complex
(Ab vs sol Ag)
-> tissue damage
Mixed Essential
Cryoglobulinaemia ag
IgM against
IgG +/-
hepatitis C
antigens
Mixed Essential
Cryoglobulinaemia path
Joint pain,
splenomegaly, skin,
nerve and kidney
involvement.
Associated with
Hep C.
Mixed Essential
Cryoglobulinaemia dx
A mixture of
clinical and
biopsies
Mixed Essential
Cryoglobulinaemia rx
NSAIDs,
Corticosteroids
and
plasmapheresis
serum sickness ag
Reaction to
Proteins in
Antiserum
(Penicillin)
serum sickness path
Rashes, Itching,
arthralgia,
lymphadenopathy,
fever and malaise.
Symptoms take 7-
12 days to develop
serum sickness dx
↓C3
Blood shows
immune
complexes or
signs of blood
vessel
inflammation.
serum sickness rx
Discontinuation
of precipitant,
steroids,
antihistamines
(+/-analgesia)
polyarteritis nodosa ag
Hep B, Hep C
virus
Antigens
polyarteritis nodosa path
Fever, fatigue,
weakness,
arthralgia, skin,
nerve and kidney
involvement,
pericarditis and MI.
Associated with
Hep B
polyarteritis nodosa dx
Diagnosed by
clinical criteria
and Biopsy
(↑ESR, ↑WCC,
↑CRP)
‘Rosary sign’
polyarteritis nodosa rx
Prednisolone
and
Cyclophosphamide
SLE ag
Mainly
intracellular
components:
DNA,
histones,
RNP
SLE path
M:F=1:9
4 of these 11:
serositis, seizures,
aphthous ulcers,
arthritis,
photosensitivity,
discoid rash, malar
rash, haematology,
kidney findings,
Antinuclear
antibody (ANA
+ve),
immunological
findings (antidsDNA, anti-sm)
