hypersensitivity disorder - type 1

Question 1

whqat is a type 1 hypersensitivity disorder

Answer 1

immediate

from Ag seen before

IgE

Mast cell release
->
* vasodilation,
* increased permeability,
* smooth muscle spasm

Question 2

sx of type 1 hypersensitivity disorder

Answer 2

Angioedema,
urticaria,
rhino conjunctivitis,
wheeze,
D&V,
ANAPHYLAXIS

Question 3

atopic dermatitis (infantile eczema) allergen

Answer 3

Irritants, food and
environmental

Question 4

atopic dermatitis (infantile eczema) pathology

Answer 4

Defects in β defensin

predispose to Staph aureus superinfection

Question 5

atopic dermatitis (infantile eczema)
dx

Answer 5

Clinical.
80% present in
first year of life.

Question 6

atopic dermatitis (infantile eczema) rx

Answer 6

Emollients, skin
oils, topical
steroids,
antibiotics, PUVA
phototherapy etc

Question 7

food allergy allergen

Answer 7

Milk, egg, peanut,
tree nut, fish,
shellfish

Question 8

food allergy path

Answer 8

IgE (anaphylaxis,
OAS);

cell mediated (coeliac);

IgE/cell mediated (atopic dermatitis)

Question 9

food allergy dx

Answer 9

Food Diary, Skin
Prick Tests,
RAST,
Challenge Test
à Most
resolve by
adulthood.

Question 10

food allergy rx

Answer 10

Dietician, Food
Avoidance,
EpiPen, Control
asthma if present

Question 11

oral allergy syndrome allergen

Answer 11

Birch pollen +
rosacea fruit,
ragweed +
melons,
mugwort + Celery
(cross- reactivity)

Question 12

oral allergy syndrome path

Answer 12

Exposure to
allergen induces
allergy to food.
Symptoms limited
to mouth, 2% get
anaphylaxis

Question 13

oral allergy syndrome dx

Answer 13

Clinical
Diagnosis, Skin
Prick Testing
can be useful

Question 14

oral allergy syndrome mx

Answer 14

Avoid food.
If ingested wash
mouth, take
antihistamine

Question 15

latex food syndrome allergen

Answer 15

Chestnut,
avocado, banana,
potato, tomato,
kiwi, papaya,
eggplant, mango,
wheat, melon

Question 16

latex food syndrome path

Answer 16

Some foods have
latex-like
components à
latex allergy
sufferers also
have food
allergies

Question 17

latex food syndrome dx

Answer 17

SPT

Question 18

latex food syndrome rx

Answer 18

avoidance

Question 19

allergic rhinitis allergen

Answer 19

Seasonal (tree
and grass pollen,
fungal spores);
Perennial (pets,
house dust mite);
Occupational
(latex, lab animals)

Question 20

allergic rhinitis path

Answer 20

Nasal itch and
obstruction,
sneezing,
anosmia, eye
symptoms

Question 21

allergic rhinitis dx

Answer 21

Pale bluish
swollen nasal
mucosa
Skin Prick Test
and RAST

Question 22

allergic rhinitis rx

Answer 22

Allergen
avoidance,
Antihistamine,
Steroid Nasal
Spray, Sodium
Cromoglycate Eye
Drops, Oral
Steroids,
Ipratropium Nasal
Spray

Question 23

acute urticaria allergne

Answer 23

50% Idiopathic
50% caused by
food, drugs, latex,
viral infections and
febrile illnesses

Question 24

acute urticaria path

Answer 24

IgE mediated
reaction. Wheals
which completely resolve in 6 wks

Question 25

acute urticaria dx

Answer 25

Mainly clinical.
(Sometimes skin
prick test)

Question 26

acute urticaria rx

Answer 26

Allergen
avoidance,
Antihistamines
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