hypersensitivity disorder - type 1 Flashcards
whqat is a type 1 hypersensitivity disorder
immediate
from Ag seen before
IgE
Mast cell release
->
* vasodilation,
* increased permeability,
* smooth muscle spasm
sx of type 1 hypersensitivity disorder
Angioedema,
urticaria,
rhino conjunctivitis,
wheeze,
D&V,
ANAPHYLAXIS
atopic dermatitis (infantile eczema) allergen
Irritants, food and
environmental
atopic dermatitis (infantile eczema) pathology
Defects in β defensin
predispose to Staph aureus superinfection
atopic dermatitis (infantile eczema)
dx
Clinical.
80% present in
first year of life.
atopic dermatitis (infantile eczema) rx
Emollients, skin
oils, topical
steroids,
antibiotics, PUVA
phototherapy etc
food allergy allergen
Milk, egg, peanut,
tree nut, fish,
shellfish
food allergy path
IgE (anaphylaxis,
OAS);
cell mediated (coeliac);
IgE/cell mediated (atopic dermatitis)
food allergy dx
Food Diary, Skin
Prick Tests,
RAST,
Challenge Test
à Most
resolve by
adulthood.
food allergy rx
Dietician, Food
Avoidance,
EpiPen, Control
asthma if present
oral allergy syndrome allergen
Birch pollen +
rosacea fruit,
ragweed +
melons,
mugwort + Celery
(cross- reactivity)
oral allergy syndrome path
Exposure to
allergen induces
allergy to food.
Symptoms limited
to mouth, 2% get
anaphylaxis
oral allergy syndrome dx
Clinical
Diagnosis, Skin
Prick Testing
can be useful
oral allergy syndrome mx
Avoid food.
If ingested wash
mouth, take
antihistamine
latex food syndrome allergen
Chestnut,
avocado, banana,
potato, tomato,
kiwi, papaya,
eggplant, mango,
wheat, melon
latex food syndrome path
Some foods have
latex-like
components à
latex allergy
sufferers also
have food
allergies
latex food syndrome dx
SPT
latex food syndrome rx
avoidance
allergic rhinitis allergen
Seasonal (tree
and grass pollen,
fungal spores);
Perennial (pets,
house dust mite);
Occupational
(latex, lab animals)
allergic rhinitis path
Nasal itch and
obstruction,
sneezing,
anosmia, eye
symptoms
allergic rhinitis dx
Pale bluish
swollen nasal
mucosa
Skin Prick Test
and RAST
allergic rhinitis rx
Allergen
avoidance,
Antihistamine,
Steroid Nasal
Spray, Sodium
Cromoglycate Eye
Drops, Oral
Steroids,
Ipratropium Nasal
Spray
acute urticaria allergne
50% Idiopathic
50% caused by
food, drugs, latex,
viral infections and
febrile illnesses
acute urticaria path
IgE mediated
reaction. Wheals
which completely resolve in 6 wks
