hypersensitivity

Question 1

what are the different types of hypersensitivity mediated by ?

Answer 1

Type1– IgE mediated

Type2– IgM and IgG antibodies against cell-surface antigens

Type3- IgM and IgG antibodies against soluble antigens and form immune
complexes

Type4– cell mediated (Tcells)

Question 2

What does type 1 cause ?

Answer 2

allergies, anaphylaxis, allergic rhinitis (‘hayfever’), eczema

Question 3

what is type 2 usually involved in ?

Answer 3

frequently involved in AI conditions

Question 4

what can type 2 cause ?

Answer 4

AI haemolytic anaemia
Graves disease
goodpastures syndrome
transfusion reaction

Question 5

explain AI haemolytic anaemia

Answer 5

type 2

blood disorder where RBCs are destroyed more rapidly than they are produced

Question 6

explain Graves disease

Answer 6

type 2

fault of thyroid stimulating hormone receptor antibodies

production of thyroxine increases and an overreactive of the thyroid glands

Question 7

explain goodpastures syndrome

Answer 7

type 2

antibodies attack the basement membranes in lungs and kidneys

Question 8

explain a transfusion reaction

Answer 8

type 2

mismatched red blood cells are rapidly destroyed by specific antibodies

Question 9

what does type 3 cause ?

Answer 9

pneumonitis
systemic lupus erythematousus
serum sickness