Hypersensitivities

Question 0

All forms of hypersensitivity require prior exposure to the antigen.
True or false?

Answer 0

True

Question 1

Which is (antibody mediated) and which is (immune complex mediated)?
– Type I  
– Type II   
– Type III 
– Type IV

Answer 1

– Type I (immediate)
– Type II (antibody mediated)
– Type III (immune complex mediated)
– Type IV (cell mediated)

Question 2

Hypersensitivity reactions can target self antigens or foreign antigens?

Answer 2

Both

– Self antigen targets result in autoimmune diseases

Question 3

Allergic or Immediate Hypersensitivity Reactions– Occur within ________ of antigen exposure?

Answer 3

minutes or hours

Question 4

APC presents peptides from the allergen on?

Answer 4

MHC IIs

Question 5

_____ cells make IgE?

Answer 5

B cells make IgE (IL-4 and IL-13 cause the class-switching to IgE)

Question 6

IgE antibodies attached to mast cells have a half life of _____?

Answer 6

several weeks.

When free floating in blood the IgE antibodies only live one day.

Question 7

IgE antibodies’_____ regions bind with high affinity to mast cells

Answer 7

Fc region binds to mast cells

Question 8

What two antibodies are good at fixing complement?

Answer 8

IgM and IgG (Me Good at fixing complement)

Question 9

Pernicious Anemia: antibodies react with intrinsic factor not permitting absorption of _____?

Answer 9

cobalamin (B12)

Question 10

With Hemolytic Anemias

– Antibodies bind to _________?

Answer 10

carbohydrates or proteins present on redblood cells. RBCs are then phagocytized

Question 11

Rheumatic heart disease is an example of which type of hypersensitivity?
What heart valve is involved?

Answer 11

Type 2 hypersensitivity,

Mitral valve.

Question 12

Lupus erythematosus is primarily is what gender

Answer 12

Women 90%

Question 13

Lupus erythematosus affects what parts of the body?

Answer 13

Lungs, joints and kidneys.

Question 14

Two types of type 4 hypersensitivity?

Answer 14

1) DTH (Delayed Type Hypersensitivity)
• Mediated by CD4 helper T cells (Th-1 and Th-17 cells)

2) Cell Mediated Cytotoxicity
•Mediated by CD8 killer T cells

Question 15

During type 4 hypersensitivity, Th-1 cells secrete large amounts of ______?

Answer 15

INF-γ stimulates macrophages
– Macrophages do most of the damage in DTH reactions
– Stimulate fibroblasts leading to fibrosis

Question 16

Examples associated with type 4 hypersensitivity?

Answer 16

– Contact dermatitis
– Crohn’s disease
– Type I diabetes (CTL attack of pancreatic β cells)
– Multiple Sclerosis