Final, Immune System Disregulation Flashcards
Molecular mimicry can be classified with what immune system dysfunction?
Autoimmune disease
What is an example of a conditions caused by defects in immune regulation?
Allergy
hyperactivate macrophages are associated with what disease?
Tuberculosis
What is the death rate of sepsis each year within the US?
250,000
overreaction to a system wide infection.
Sepsis
What are the most common allergies?
Hay fever, asthma, atopic dematitis, food allergies
During a non-allergic response the body produce which antibody?
IgG
The Fab or Fc region of IgE bind to mast cells?
Fc (Fab binds to the allergen which triggers degranulation)
clustering sends a signal downstream promoting degranulation of mast cells releasing all of the following except? a. histamine b. proteases c. enkephalins d. heparin
c. enkephalins
The degranulation of mast cells is associated with which allergy phase?
Immediate or delayed
Immediate (delayed reaction takes cells secrete IL-5 which recruits eosinophils from the bone marrow).
What acts as a “guidance system” for mast cells, basophils, & eosinophils targeting their chemistry at the parasite to destroy it?
IgE
The placenta produces large quantities of _____ which causes both maternal and fetal helper T cells to become Th2.
IL-4
The “snot nosed kid” is thought to aid in what shift?
Shifting Th2 back to Th1
Allergy concordance in identical twins is what %?
50%
People who are atopic are more likely to have inherited what particular class of genes?
class II MHC genes
As a treatment for allergies what works by blocking cytokine production by Th cells activating fewer B cells?
Glucocorticoids (cortisol)
Genetic defect where T cells refuse to die when chronically
stimulated by self antigens (defect in apoptosis due to genetic defect in Fas or Fas ligand proteins
Autoimmune lymphoproliferative syndrome
