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Immunology > Hypersensitivies III > Flashcards

Hypersensitivies III Flashcards

1
Q

Timing of clinical signs of type III?

A

within hours if prior sensitized

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2
Q

What cells are involved in type III?

A

neutrophils, some mast cells

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3
Q

What Ig classes for type III?

A

IgG, IgA

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4
Q

Clinical syndrome type III?

A

Immune complexes deposit on capillaries, complement activation leads to immune complex disease

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5
Q

Immune complex disease associated with type III?

A

vasculitis, glomerulonephritis, arthritis

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6
Q

What is the mechanism of type III?

A

immune complex formation in vessels that leads to inflammatory response

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7
Q

What are the three phases of type III mechanism?

A

1- immune complex (antigen-antibody) deposits in tissues/blood vessels

2- complement cascade is activated

3- activation of neutrophils / mast cells

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8
Q

What proteins are released to recruit neutrophils and mast cells?

A

chemotactic complement proteins (C3a and C5a)

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9
Q

What happens as a result of the activation of neutrophils and mast cells?

A

leads to release of enzymes and ROS that damage tissues/vessels

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10
Q

MAC is not a player in type III. True or false?

A

true

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11
Q

What is the result of type III reaction to subcutaneous exposure? What is the site of immune-complex exposure?

A

arthus reaction; perivascular area

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12
Q

What is the result of type III reaction to inhaled exposure? What is the site of immune-complex exposure?

A

Farmer’s Lung( or heaves in horses); alveolar/capillary interface

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13
Q

What causes Farmer’s Lung?

A

release of protein from neutrophils damages lungs

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14
Q

What is the antigen for inhaled type III reactions?

A

fungal spores

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15
Q

What is the result of type III reaction to IV exposure? What is the site of immune-complex exposure?

A

vasculitis - blood vessel walls

nephritis- renal glomeruli

arthritis- joint spaces

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16
Q

What is happening in “blue eye”?

A

Ag-Ab complexes to canine MLV adenovirus vaccine I or infection deposits in cornea

17
Q

What are the symptoms of blue eye?

A

corneal edema (fluid accumulation) and opactiy

18
Q

What test would you run for glomerulonephritis?

A

direct immunofluorescent antibody test

fluorescent anti-species IgG on tissue biopsies

19
Q

What is the only local type III reaction we talked about?

A

blue eye

20
Q

What is pneumonitis commonly called?

A

Farmers lung in people or heaves in horses to moldy hay

21
Q

What are three types of serum sickness in horses and humans?

A

immune complex formation deposits in vessels of:

liver (hepatitis)
kidney (glomerulonephritis)
joints (arthritis)

22
Q

What is the cause of serum sickness?

A

anti-tetanus serum or anti-venom serum

23
Q

Feline infectious peritonitis virus-vasculitis is a systemic type III reaction. Yay or nay?

A

yay

24
Q

Glomerulonephritis is associated with lyme disease. True or false?

A

true

25
Q

Major lesion for streptococcus equi?

A

purpura

26
Q

Major lesion for staphylococcus aureus?

A

dermatitis

27
Q

Major lesion for canine adenovirus-1?

A

uveitis, glomerulonephritis

28
Q

Major lesion for hog cholera?

A

glomerulonephritis

29
Q

Major lesion for african swine fever virus?

A

glomerulonephritis

30
Q

Major lesion for equine virl arteritis?

A

arteritis

31
Q

Major lesion for equine infectious anemia virus?

A

glomerulonephritis

32
Q

How do you treat type III reactions?

A

suppress immune response

glucucorticoids
cyclophosphamide

33
Q

In type III reactions, the pathogen is the cause of clinical syndrome. True or false?

A

False- often the pathogen is long gone and the immune response is responsible for the clinical syndrome

Immunology (11 decks)

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