Hypersensitivies III Flashcards
Timing of clinical signs of type III?
within hours if prior sensitized
What cells are involved in type III?
neutrophils, some mast cells
What Ig classes for type III?
IgG, IgA
Clinical syndrome type III?
Immune complexes deposit on capillaries, complement activation leads to immune complex disease
Immune complex disease associated with type III?
vasculitis, glomerulonephritis, arthritis
What is the mechanism of type III?
immune complex formation in vessels that leads to inflammatory response
What are the three phases of type III mechanism?
1- immune complex (antigen-antibody) deposits in tissues/blood vessels
2- complement cascade is activated
3- activation of neutrophils / mast cells
What proteins are released to recruit neutrophils and mast cells?
chemotactic complement proteins (C3a and C5a)
What happens as a result of the activation of neutrophils and mast cells?
leads to release of enzymes and ROS that damage tissues/vessels
MAC is not a player in type III. True or false?
true
What is the result of type III reaction to subcutaneous exposure? What is the site of immune-complex exposure?
arthus reaction; perivascular area
What is the result of type III reaction to inhaled exposure? What is the site of immune-complex exposure?
Farmer’s Lung( or heaves in horses); alveolar/capillary interface
What causes Farmer’s Lung?
release of protein from neutrophils damages lungs
What is the antigen for inhaled type III reactions?
fungal spores
What is the result of type III reaction to IV exposure? What is the site of immune-complex exposure?
vasculitis - blood vessel walls
nephritis- renal glomeruli
arthritis- joint spaces
What is happening in “blue eye”?
Ag-Ab complexes to canine MLV adenovirus vaccine I or infection deposits in cornea
What are the symptoms of blue eye?
corneal edema (fluid accumulation) and opactiy
What test would you run for glomerulonephritis?
direct immunofluorescent antibody test
fluorescent anti-species IgG on tissue biopsies
What is the only local type III reaction we talked about?
blue eye
What is pneumonitis commonly called?
Farmers lung in people or heaves in horses to moldy hay
What are three types of serum sickness in horses and humans?
immune complex formation deposits in vessels of:
liver (hepatitis)
kidney (glomerulonephritis)
joints (arthritis)
What is the cause of serum sickness?
anti-tetanus serum or anti-venom serum
Feline infectious peritonitis virus-vasculitis is a systemic type III reaction. Yay or nay?
yay
Glomerulonephritis is associated with lyme disease. True or false?
true
