Huntingtons Flashcards
1
Q
What chromosome is affected in Huntington’s & what’s the defect?
A
CAG repeats on chromosome 4
2
Q
What cause Huntingtons?
A
Death of striatal cells containing GABA and Acetylecholine resulting in a decrease in GABA and an increase in Dopamine.
3
Q
Symptoms of Huntingtons?
A
Irritation, Depression Decreased Coordination Chorea Hyperkinesia Dementia Fits
4
Q
What treatments slow progression?
A
None
5
Q
What is the inheritance pattern of Huntingtons?
A
Autosomal Dominant
