Horses

Question 1

MEEDS

Answer 1

exfoliative dermatitis, ulcerative stomatitis, wasting, and infiltration of epithelial tissues by eosinophils, lymphocytes, and macrophages.

Question 2

Clinical symptoms MEEDS

Answer 2

-scaling, crusting, oozing, alopecia, and fissures on the coronets and/or the face
-oral ulceration
-well-demarcated ulcers on the coronary bands, muzzle, and mucocutaneous junctions

-vesicles and bullae are seen in these areas, or urticarial eruption
-variable lymphadenopathy and pruritus

-ventral edema, diarrhea (50%) + intestinal malabsorption

Question 3

Histo of MEEDS

Answer 3

• superficial and deep perivascular, lichenoid interface, interstitial, diffuse, and granulomatous
  -Eosinophils, lymphocytes, and plasma cells
  -irregular Epidermal hyperplasia
  -Hyperkeratosis- Orto/para.
• epitheliotropic infiltration of eosinophils and lymphocytes is typical, and apoptotic keratinocytes may be prominent
  -eosinophil/neutrophilic micro abscesses

Question 4

Th for MEEDS

Answer 4

2.2-4.4 mg/kg prednisolone or prednisone every 24 h, or 0.1-0.4 mg/kg dexametha- sone every 24 h
-dexameth- asone and hydroxyurea (20 mg/kg PO every 24 h

-food trial!

Question 5

synonyms for sarcoidosis

Answer 5

idiopathic, generalized, or systemic granulomatous disease; equine histiocytic disease; equine histiocytic dermatitis

Question 6

causes of sarcoidosis

Answer 6

-unknown
-immunologic reaction to infectious agent or allergen

Mycobacterium intra- cellulare serotype 8 ,Borrelia burgdorferi, Mycobacterium spp., Coccidioides immitis, Cryptococcus neoformans, Corynebacterium pseudo- tuberculosis, Borrelia burgdorferi, equine herpesvirus 1, and equine herpesvirus 2
-hairy vetch (Vicia sp.) toxicosis?

Question 7

Clinical features of sarcoidosis

Answer 7

-geldings
-scaling, crusting, and alopecia on the face, trunk (especially shoulder and girth), or legs, and progresses to a multi- focal or generalized exfoliative dermatitis
-variable pruritus, pain , enlargement of LN

-exercise intolerance, poor appetite, weight loss, ventral edema, and persistent low-grade fever

-isolated hyperkeratotic, crusted, alopecic plaques, especially on the lower legs

Question 8

Histo sarcoidosis

Answer 8

-nodular- to-diffuse sarcoidal granulomatous dermatitis that may affect all portions of the dermis
- Multinucleated histiocytic giant cells are numerous

Question 9

Th for sarcoidosis

Answer 9

-spontaneous remission
-GC

Immunosuppressive doses of glucocorticoids (prednisolone or prednisone 2- 4 mg/kg PO every 24 h; dexamethasone 0.2-0.4 mg/kg PO every 24 h) may be effective if administered early in the course of the disease

-omega 6/omega 3 fatty acids+ PTX