Hormones That Act On The Kidney

Question 1

Stimulus for secretion of PTH

Answer 1

Decreased plasma Ca

Question 2

Stimuli for ADH secretion (2)

Answer 2

Increased plama osmolarity

Decreased blood volume

Question 3

Stimuli fo aldosterone secretion (2)

Answer 3

Increased plasma K

Decreased blood volume (via RAAS)

Question 4

Stimulus for ANP secretion

Answer 4

Increased atrial pressure

Question 5

Stimulus for angiotensin II secretion

Answer 5

Decreased blood volume

Question 6

Time course

PTH

Answer 6

Fast

Question 7

Time course

ADH

Answer 7

Fast

Question 8

Time course

Aldosterone

Answer 8

Slow

Question 9

Time course

ANP

Answer 9

Fast

Question 10

Time course

Angiotensin II

Answer 10

Fast

Question 11

MOA

PTH

Answer 11

Increased cAMP—> urine

Question 12

MOA

ADH

Answer 12

Basolateral V2 receptor—> cAMP

(Note: V1 receptors are on blood vessels; mechanism is IP3 Ca

Question 13

MOA

Aldosterone

Answer 13

New protein synthesis

Question 14

MOA

ANP

Answer 14

CGMP

Question 15

Action on kidney

PTH on Phospate, Ca, 1a-hydroxylase

Answer 15

Decreased phosphate reabsorption ( PCT)
Increased Ca reabsorption
Activation of 1a hydroxylase

Question 16

Action on kidney

ADH

Answer 16

Inceased water permeability on late distal tubule and collecting duct principal cells

Question 17

Action on kidney

Aldosterone on Na, K, H

Answer 17

Increased Na reabsorption (ENac, distal tubule principal cells)
Increased K secretion (distal tubule principal cells)
Increased H+ secretiom (distal tubule a-intercalated cells)

Question 18

Action on kidney

ANP

Answer 18

Increased GFR

Decreased Na reabsorption

Question 19

Action on kidney

Angiotensin II

Answer 19

Increased Na-H exchange and HCO3- reabsorption (PCT)