Hormone Replacement Therapy (HRT)

Question 1

Define Hormone Replacement Therapy (HRT)

Answer 1

se of exogenous oestrogens when endogenous secretion is absent

Question 2

Outline the various preperations of HRT

Answer 2

Oestrogen alone for hysterectomized women
+ Progestogen otherwise
-Oral, patch, gel, implant, topical [vaginal cream, ring or tablet]

Question 3

Outline the advantages of HRT

Answer 3

Relief from menopausal symptoms
Protects against osteoporosis
Reduces urinary symptoms
Treatment of choice for women with premature menopause

Question 4

Outline the disadvantages of HRT

Answer 4

Menstruation unless ‘period-free’ preparation
Oestrogenic & progestogenic side effects
Inc risk of breast cancer [with progestogen HRT]
Inc risk of venous thromboembolism [oral]