Homework 2 Flashcards
which of the following cell groups are considered highly sensitive?
a. lymphocytes, spermatogonia, erythoblasts, and intestinal crypt cells
b. endothelial cells, osteoblasts, spermatids, and fibroblasts
c. muscle and nerve cells, and chondrocytes
d. mucle cells and osteoblasts
a. lymphocytes, spermatogonia, erythoblasts, and intestinal crypt cells
Relative biologic effectiveness (RBE):
a. describes a measure of the rate at which energy is deposited as a charged particle travels through matter.
b. is a comparison of a dose of test radiation to a dose of 250-keV X-ray that produces the same biologic response.
c. is defined as the dose of radiation that produces a given biologic response under
anoxic conditions divided by the dose of radiation that produces the same biologic response under aerobic conditions.
d. states that stem cells are more radiosensitive than mature cells.
b. is a comparison of a dose of test radiation to a dose of 250-keV X-ray that
produces the same biologic response.
Which of the following body molecules are most commonly acted upon directly by ionizing radiation to produce indirect effects? a. lipids b. proteins c. carbohydrates d. water
d. water
The types of DNA molecule damage include:
- main-chain scission, one side rail broken
- main-chain scission, both side rails broken
- main-chain scission, resulting in cross-linking
- rung breakage, causing bases to separate
- a changing or loss of a base
a. 1 only
b. 2 and 3 only
c. 5 only
d. 1, 2, 3, 4, and 5
d. 1, 2, 3, 4, and 5
At low doses of radiation, most cellular radiation damage is the result of:
a. main-chain scission.
b. cross-linking.
c. point lesions.
d. gender.
c. point lesions
Nonthreshold:
a. means that an observed response is directly proportional to the dose.
b. means that an observed response is not directly proportional to the dose.
c. assumes that there is a radiation level reached under which there would be no effects observed.
d. assumes that any radiation dose produces an effect
d. assumes that any radiation dose produces an effect
According to target theory:
a. only direct effects can cause hits.
b. only indirect effects can cause hits.
c. RNA is considered the critical target.
d. DNA is considered the critical target.
d. DNA is considered the critical target.
Altering of a chromosome by a portion of it transferring either to another chromosome or to another section of the same chromosome
Translocation
A chromosome that has two centers or two centromeres
Dicentric
A measure of the rate at which energy is deposited from ionizing radiation to soft tissue
Linear energy transfer (LET)
A structural change or transformation of a chromosome that can be transmitted to offspring
Mutation
A group of cells that perform a particular function
System
A graphical representation of observed effects compared with radiation dose
Dose-response relationship (curve)
Cell death occurring before mitosis
interphase death
The amount of reaction or response of a cell to radiation
Radiosensitivity
Mutation of chromosome causing it to become ring-shaped
Ring
Enhanced cell response due to aerobic conditions
Oxygen effect
An atom that has an unpaired electron, making it highly reactive
free radical
Assist in protein synthesis
ribosomes