Homeostasis Of Fluid Balance Flashcards

1
Q

Intracellullar fluid

A

Within cells,within PM of cells

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2
Q

Extracellular fluid

A

Outside of cells, interstitual fluid and plasma (all fluid within cells)

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3
Q

Interstitial fluid

A

Between cells

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4
Q

Plasma

A

Within blood

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5
Q

Osmosis

A

movement of water according to concentration gradient

Osmotic Pressure changes with blood pressure and relative solute concentration between fluid compartments

Fluid moves between blood stream and interstitial fluid based on osmotic pressure

Fluid moves between intracellular fluid and interstitial fluid based on osmotic pressure

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6
Q

Excretion

A

removal of waste products of metabolism and toxins

After filtration, to remove them via urine

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7
Q

Regulation of blood volume and pressure

A

Excretion of appropriate volume of dilute or concentrated urine

Either large volume of dilute urine or small amount of ( ) ed urine. Depends on hydration levels

More fluid= increase dilute urine, less fluid= decrease concentrated urine

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8
Q

Regulation of blood solute concentrations

A

Selective reabsorption or excretion of glucose, Na+, Cl-, K+, Ca++, HCO3-, HPO42-

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9
Q

Regulation of extracellular fluid pH

A

Modify excretion of H+(protons) to regulate pH

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10
Q

Regulation of Red blood cell synthesis

A

Secrete hormone, erythropoietin, that stimulates red blood cell production

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11
Q

Regulation of vitamin D synthesis

A

Important role in regulating Ca++ concentration

By regulating synthesis of vitamin D

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12
Q

Cortex

A

Involved in the formation of urine for excretion

Outer region

Blood filtration

Initial, formation of filtrate

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13
Q

Medulla

A

Involved in the formation of urine for excretion

Inner region

modification of filtrate into urine— 90% gets absorbed back into blood

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14
Q

Filtration

A

At Renal Corpuscle(network of capillaries),(glomerulus and bowmans capsule)

Separation based on size

Water, ions move through becoming filtrate (~180 L/day)— afferent arteriole supplies blood to glomerulus for filtration.
Efferent transports filtered blood away

Blood cells, proteins stay in blood circulation—have increase pressure due to small diameter of efferent over afferent

Highly permeable because of pores, neither large proteins or blood cells can fit through glomerulus

Non selective based on size and charge

First selection of nephron

Driving force is PB

Blood enters the renal corpuscle to move through the glomerulus network of capillaries

Movement of fluid and ions

Filtration membrane in Bowman capsule blocks red blood cells and proteins from leaving blood stream

Filtered fluid, containing water, ions, waste, glucose, known as filtrate enters the Proximal Tubule

Blood pressure in glomerular capillaries forces fluids and small molecules out of the blood to create filtrate

Allows toxins to be quickly removed from blood

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15
Q

Tubular Reabsorption

A

At Proximal convoluted tubule and Loop of Henle

More microvilli increase SA

Water, ions and glucose brought back into circulation

Transport of water and solutes (ions, glucose) from filtrate back into the blood

Blood filtered= 25x/day

Driven by osmosis, diffusion and transport proteins
Figure 99% of filtrate – water, solutes, amino acids, glucose leave tubules into interstitial fluid and then reenter blood stream

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16
Q

Tubular Secretion

A

At Distal convoluted tubule Movement of non-filtered substances from the blood into filtrate

Fewer microvilli

What wasn’t filtered originally

17
Q

Filtration – Net Filtration Pressure

A

Driving forces of fluid

1.Blood within Glomerular Capillaries is at high pressure, due to small efferent (exit) arteriole. (50 mmHg) BP, outward pressure

Forces fluid and solutes out and into Bowman capsule

  1. Filtered fluid creates a capsule
    pressure(-10 mmHg) that also opposes filtration
  2. Proteins remaining in capillary create a colloid osmotic pressure (-30 mmHg) (due to concentration gradient) that opposes filtration—Proteins that remain help with this process

Osmosis draws protein to draw back fluid into glomerular capillary from Bowman’s capsule

Net Filtration pressure results in fluid movement into Proximal tubule

50 – 30 – 10 = 10 Net Filtration Pressure

18
Q

Proximal Convoluted Tubule

A

Site of majority of reabsorption

Transport proteins move H2O to some filtered molecules from filtrate back into blood in peritubular capillaries

Tubule lined with cells that have
microvilli (finger like projections)
to increase surface area for absorption—more transporters

Na+ actively transported out of cells, creating concentration gradient for Na+ to move in from lumen of tubule—from filtrate to cytoplasm

Transporters for amino acids,
glucose carry their specific molecules out of lumen into cells

Secondary active transport
with Na+—creates [ ] gradient

Water follows Na+ and and other
solutes by osmosis

19
Q

Blood flow through kidney

A

Blood enters through Afferent Arteriole

Glomerulus provides large surface area for filtration

Blood exits through Efferent Arteriole

20
Q

Peritubular Capillaries

A

Blood flow around renal tubules

reabsorption of select portions of filtrate

blood flows in the same direction as filtrate in Proximal tubule, distal tubule and collecting duct

21
Q

Vasa recta

A

Maintains, increase [ ] of solutes in interstiual fluid

Blood flow through vasa recta to veins

Blood flows in the opposite direction to filtrate in loop of Henle

Counter current exchange important for—from flowing opposite directions, as fluids pass each other, materials can be exchanged between them

22
Q

Descending Loop of
Henle

A

simple squamous cells (highly permeable to H2O)

Cells of Descending limb are permeable to water

Water moves out into interstitial fluid by osmosis (out of descending limb)

Water moves into vasa recta by osmosis

Solutes move into descending limb by diffusion

At bottom of limb, 15% of filtrate
volume has been reabsorbed and it is now much more concentrated (water removed and solute added)

23
Q

Thin Ascending Loop of
Henle

A

Cells of the thin ascending limb are not permeable to water

Cells are permeable to some solutes— which exit, reducing ( ) of filtrate

As filtrate travel up loop of henle solutes leave tubule into interstitial fluid

Interstitial fluid is very concentrated in medulla and less concentrated in cortex

As blood flows in opposite direction, it continues to enter a more and more concentrated environment as it descends into medull

Solute reabsorbed into the blood.
Filtrate becomes less concentrated as it ascends

24
Q

Thick Ascending Loop of Henle

A

Thick ascending limb is impermeable to both water and
solute

Cells of the thick ascending have active transporters for sodium (Na+) powered by ATP on the inside surface (tubule side)

carrier molecules remove solutes from filtrate and the enter interstitual fluid

Co-transport of potassium (K+) and Chloride (Cl-) ions along with active transport of Na+

Solutes transported into cells of thick ascending limb diffuse into interstitial fluid and then move into
descending vasa recta

Through Loop of Henle

—water removed by osmosis in descending loop

—Solutes removed by diffusion in thin ascending loop

—Solutes transported out in thick ascending loop

25
Distal Tubule and Collecting duct of nephron
K+ and H+ not always permeable to H2O, but hormonal reg can change this High blood volume leads to increased blood pressure Inhibit ADH – decreasing water reabsorption Inhibit renin and aldosterone and increased ANH - decreases Na+ reabsorption Vasodilation of renal arteries increasing filtration – more water lost in filtrate When ADH is present reabsorption of H2O through wall of distal tubule and collecting duct Overall reduction in blood volume through greater water and Na+ loss in urine
26
Renin-angiotensin system
Imp. When theres a drop in DP 1.renin 2.angiotensin 2 3.aldosterone 1.When BP is decreased, kidneys detect and increase renin secretion into circulatory. Results:vasoconstriction Increase H2O reabsorption, decrease urine formation 2.Renin travels through blood and acts on angiotensin to make angiotensis 1 3. enzyme: angiotensin converting enzyme acts on angiotensin 1 to convert it to its a tive for, angliotensin 2 4.angiotensin 2 is a vasoconstrictor—increases blood pressure 5.angiotensin 2 acts on adrenal cortex to increase secretion of aldosterone 6.aldosterone acts on kidneys, causing them to conserve Na+ and H2O— water volume lost from blood into urine is reduced— less fluid loss so blood volume is maintained—adequate BV is essential to maintain normal venous return to heart and maintain BP
27
Homeostasis disturbed-high blood volume induces elevated blood pressure
Stimulus—receptors and control centers; Pituitary—baroreceptors inhibit posterior pituitary ADH secretion when blood volume increases. Kidney—juxtaglomerular apparalli inhibit renin release when blood volume increases, which decreases aldosterone secretion. Heart—atrial cardiac muscle cells secrete ANH when blood volume increases. Blood vessels—sympathetic division barocepters detect increased blood volume, which causes vasodialation of renal arteries Response—effectors; Decreased ADH decreases water reabsorption by the distal convoluted tubules and collecting ducts. Less water returns to the blood and more water is lost in the urine, which decreases blood volume . Decreased aldosterone and increased ANH decrease Na+ reabsorption from the distal convoluted tubule and collecting duct. More Na+ and water are lost in the urine, which decreases blood volume. Increased renal blood flow increases the rate of filtrate formation, and more water is lost in the urine Homeostasis restored—reduced blood volume due to loss of water and Na+ in the urine lowers blood pressure
28
Anti-diuretic Hormone
To increase urine process Anti this would be to decrease ADH Secreted by posterior pituitary neurons when solute concentration of blood or interstitial fluid increases or blood pressure falls promotes H2O conservation Increases permeability of collecting duct cells to water by opening water pores and adding them More water reabsorbed Lower volume of more concentrated urine secretion regulated by changes In BP baroreceptors monitor BP detect significant decrease, ADH secretion increases and vise versa
29
Sources of water loss from body
Evaporation from skin—sweat, exercise; increases in hot environment to maintain core temperature— even more in dry environment Exhalation of warmed and moistened air—we do this when the air comes in—increases in a dry environment as air taken in has less moisture—not much with each breath, but sum all the breaths Excretion in Urine—Modified based on hydration status, impacting blood pressure and blood solute concentrations Loss in feces Intake required to balance losses—You should be able to maintain your body fluid volume very consistently Take in more water if you exercise, especially if in heat for prolonged periods. Keep in mind water from fruits and vegetables constitutes as they have a high-water content
30
Tubular Secretion
Weren’t initially filtered Movement of non-filtered substances from the blood into the filtrate. Active or passive movement of toxic by-products from metabolism (ammonia), drugs and other molecules Certain tubule cells transport additional solutes from blood into filtrate Potassium, bicarbonate and proton (pH) levels in the blood can be regulated through modification of tubular secretion through hormonal control mechanisms
31
Homeostasis disturbed—blood PH decreases(H+ increases)
Stimulus—receptors and control centers; Buffers—buffers bind H+.H2O +CO2 <-H2CO3<-H+HCO3. Lungs—the respiratory control center in the brain increases the rate and depth of respiration, which decreases blood flow. Kidney—the distal convoluted tubules increase H+ secretion into the urine, and increase HCO3 reabsorption into the blood. getting rid of more protons, keeping bicarbonate Response—effectors; The number of H+ in the blood decreases.—bring PH up Decreased blood CO2 causes H+ to react with HCO3 to form carbonic acid, which decreases H+ in the blood H2O+CO2 <-H2CO3 <-H+ + HCO3- More H+ are removed from the blood and more HCO3- are available to bind H+
32
HOMEOSTASIS DISTURBED—Blood pH increases (H+ decreases)
Stimulus—receptors and control centers; Kidney—The distal convoluted tubules decrease H+ secretion into the urine and decrease HCO3-reabsorption into the blood. Lungs—The respiratory control center in the brain decreases the rate and depth of respiration, which increases blood CO2 Buffers—buffers release H+ H2O + CO2 ->H2CO3 ->H+ + HCO3- Response—effectors; Fewer H* are removed from the blood, and fewer HCO3- are available to bind H+ Increased blood CO2 reacts with water to produce carbonic acid, which dissociates to increase H+ H2O+ CO2 —> H2CO3 >H+ + HCO3- The number of H* in the blood increases. Homeostasis restored—blood PH decreases(H+ increases)