Homeostasis Of Fluid Balance Flashcards
Intracellullar fluid
Within cells,within PM of cells
Extracellular fluid
Outside of cells, interstitual fluid and plasma (all fluid within cells)
Interstitial fluid
Between cells
Plasma
Within blood
Osmosis
movement of water according to concentration gradient
Osmotic Pressure changes with blood pressure and relative solute concentration between fluid compartments
Fluid moves between blood stream and interstitial fluid based on osmotic pressure
Fluid moves between intracellular fluid and interstitial fluid based on osmotic pressure
Excretion
removal of waste products of metabolism and toxins
After filtration, to remove them via urine
Regulation of blood volume and pressure
Excretion of appropriate volume of dilute or concentrated urine
Either large volume of dilute urine or small amount of ( ) ed urine. Depends on hydration levels
More fluid= increase dilute urine, less fluid= decrease concentrated urine
Regulation of blood solute concentrations
Selective reabsorption or excretion of glucose, Na+, Cl-, K+, Ca++, HCO3-, HPO42-
Regulation of extracellular fluid pH
Modify excretion of H+(protons) to regulate pH
Regulation of Red blood cell synthesis
Secrete hormone, erythropoietin, that stimulates red blood cell production
Regulation of vitamin D synthesis
Important role in regulating Ca++ concentration
By regulating synthesis of vitamin D
Cortex
Involved in the formation of urine for excretion
Outer region
Blood filtration
Initial, formation of filtrate
Medulla
Involved in the formation of urine for excretion
Inner region
modification of filtrate into urine— 90% gets absorbed back into blood
Filtration
At Renal Corpuscle(network of capillaries),(glomerulus and bowmans capsule)
Separation based on size
Water, ions move through becoming filtrate (~180 L/day)— afferent arteriole supplies blood to glomerulus for filtration.
Efferent transports filtered blood away
Blood cells, proteins stay in blood circulation—have increase pressure due to small diameter of efferent over afferent
Highly permeable because of pores, neither large proteins or blood cells can fit through glomerulus
Non selective based on size and charge
First selection of nephron
Driving force is PB
Blood enters the renal corpuscle to move through the glomerulus network of capillaries
Movement of fluid and ions
Filtration membrane in Bowman capsule blocks red blood cells and proteins from leaving blood stream
Filtered fluid, containing water, ions, waste, glucose, known as filtrate enters the Proximal Tubule
Blood pressure in glomerular capillaries forces fluids and small molecules out of the blood to create filtrate
Allows toxins to be quickly removed from blood
Tubular Reabsorption
At Proximal convoluted tubule and Loop of Henle
More microvilli increase SA
Water, ions and glucose brought back into circulation
Transport of water and solutes (ions, glucose) from filtrate back into the blood
Blood filtered= 25x/day
Driven by osmosis, diffusion and transport proteins
Figure 99% of filtrate – water, solutes, amino acids, glucose leave tubules into interstitial fluid and then reenter blood stream
Tubular Secretion
At Distal convoluted tubule Movement of non-filtered substances from the blood into filtrate
Fewer microvilli
What wasn’t filtered originally
Filtration – Net Filtration Pressure
Driving forces of fluid
1.Blood within Glomerular Capillaries is at high pressure, due to small efferent (exit) arteriole. (50 mmHg) BP, outward pressure
Forces fluid and solutes out and into Bowman capsule
- Filtered fluid creates a capsule
pressure(-10 mmHg) that also opposes filtration - Proteins remaining in capillary create a colloid osmotic pressure (-30 mmHg) (due to concentration gradient) that opposes filtration—Proteins that remain help with this process
Osmosis draws protein to draw back fluid into glomerular capillary from Bowman’s capsule
Net Filtration pressure results in fluid movement into Proximal tubule
50 – 30 – 10 = 10 Net Filtration Pressure
Proximal Convoluted Tubule
Site of majority of reabsorption
Transport proteins move H2O to some filtered molecules from filtrate back into blood in peritubular capillaries
Tubule lined with cells that have
microvilli (finger like projections)
to increase surface area for absorption—more transporters
Na+ actively transported out of cells, creating concentration gradient for Na+ to move in from lumen of tubule—from filtrate to cytoplasm
Transporters for amino acids,
glucose carry their specific molecules out of lumen into cells
Secondary active transport
with Na+—creates [ ] gradient
Water follows Na+ and and other
solutes by osmosis
Blood flow through kidney
Blood enters through Afferent Arteriole
Glomerulus provides large surface area for filtration
Blood exits through Efferent Arteriole
Peritubular Capillaries
Blood flow around renal tubules
reabsorption of select portions of filtrate
blood flows in the same direction as filtrate in Proximal tubule, distal tubule and collecting duct
Vasa recta
Maintains, increase [ ] of solutes in interstiual fluid
Blood flow through vasa recta to veins
Blood flows in the opposite direction to filtrate in loop of Henle
Counter current exchange important for—from flowing opposite directions, as fluids pass each other, materials can be exchanged between them
Descending Loop of
Henle
simple squamous cells (highly permeable to H2O)
Cells of Descending limb are permeable to water
Water moves out into interstitial fluid by osmosis (out of descending limb)
Water moves into vasa recta by osmosis
Solutes move into descending limb by diffusion
At bottom of limb, 15% of filtrate
volume has been reabsorbed and it is now much more concentrated (water removed and solute added)
Thin Ascending Loop of
Henle
Cells of the thin ascending limb are not permeable to water
Cells are permeable to some solutes— which exit, reducing ( ) of filtrate
As filtrate travel up loop of henle solutes leave tubule into interstitial fluid
Interstitial fluid is very concentrated in medulla and less concentrated in cortex
As blood flows in opposite direction, it continues to enter a more and more concentrated environment as it descends into medull
Solute reabsorbed into the blood.
Filtrate becomes less concentrated as it ascends
Thick Ascending Loop of Henle
Thick ascending limb is impermeable to both water and
solute
Cells of the thick ascending have active transporters for sodium (Na+) powered by ATP on the inside surface (tubule side)
carrier molecules remove solutes from filtrate and the enter interstitual fluid
Co-transport of potassium (K+) and Chloride (Cl-) ions along with active transport of Na+
Solutes transported into cells of thick ascending limb diffuse into interstitial fluid and then move into
descending vasa recta
Through Loop of Henle
—water removed by osmosis in descending loop
—Solutes removed by diffusion in thin ascending loop
—Solutes transported out in thick ascending loop