Hodgkin Lymphoma Flashcards
A neoplastic proliferation of Reed-Sternberg cells?
Hodgkin Lymphoma
What are Reed-Sternberg cells?
Large B cells with multilobed nuclei and prominent nucleoli (owl-eyed nuclei)
What are Reed-Sternberg cells classically positive for?
CD15 and CD30
What are the ‘B’ symptoms associated with Hodgkins lymphoma caused by the release of cytokines from the Reed-Sternberg cells?
Fever
Chills
Weight loss
Night Sweats
What cells are attracted by the cytokines released by the Reed-Sternberg cells that make up the bulk of the mass and may lead to fibrosis?
Lymphocytes
Plasma cells
Macrophages
Eosinophils
What are the 4 subtypes of tumors, caused by reactive inflammatory cells, used to classify Hodgkin lymphoma?
Nodular sclerosis
Lymphocyte-rich
Mixed cellularity
Lymphocyte-depleted
What is the most common subtype of Hodgkin lymphoma?
Nodular sclerosis
What is the classic presentation of nodular sclerosis Hodgkin Lymphoma?
Enlarging cervical or mediastinal lymph node in a young, female adult
What is the typical appearance of nodular sclerosis Hodgkin lymphoma seen on microscopy?
Lymph nodes that are divided by sclerotic bands with Reed-Sternberg cells in the center of the bands
Which subtype of Hodgkin lymphoma has the best prognosis?
Lymphocyte-rich
What cells are associated with mixed cellularity Hodgkin lymphoma?
Eosinophils
What do the Reed-Sternberg cells seen in mixed cellularity Hodgkin lymphoma produce?
IL-5
Which subtype of Hodgkin lymphoma is the most aggressive and usually presents in the elderly or HIV positive patients?
Lymphocyte-depleted
