Epithelial tumors Flashcards
A 72 year old patient presents with a raised, discolored plaque on her arms, legs and face. The lesion has a stuck on appearance and represents a benign squamous proliferation. What is the most likely diagnosis for this patient?
Seborrheic Keratosis
What is the characteristic finding seen on histology with seborrheic keratosis?
Keratin pseudocytes
A patient presents with a sudden onset of multiple seborrheic keratoses? What is this phenomenon called and what does it suggest?
Leser-Trelat sign
Suggests underlying carcinoma of the GI tract
Epidermal hyperplasia with darkening of the skin that usually involves the axilla or the groin…
Acanthosis nigricans
What are the 2 abnormalities associated with acanthosis nigricans?
Insulin resistance
Malignancy—especially gastric carcinoma
A malignant proliferation of the basal cells of the epidermis…
Basal cell carcinoma
What are the 3 common risk factors for the development of basal cell carcinoma?
Prolonged exposure to sunlight
Albinism
Xeroderma pigmentosum
What is the presentation of basal cell carcinoma?
Elevated nodule with a central, ulcerated crater that is surrounded by dilated vessels (telangiectatic)
Where is the classic location of basal cell carcinoma?
Upper lip
What is seen on histology of basal cell carcinoma?
Nodules of basal cells with peripheral palisading
What is the treatment for basal cell carcinoma?
Surgical excision
A malignant proliferation of squamous cells that is characterized by the formation of keratin pearls…
Squamous cell carcinoma
What are the most common risk factors contributing to the development of squamous cell carcinoma?
Prolonged exposure to sunlight Albinism Xeroderma pigmentosum Immunosuppressive therapy Arsenic exposure Chronic inflammation
Where is the classic site for squamous cell carcinoma development?
Lower lip
What is the treatment for squamous cell carcinoma?
Excision of mass
