HMP Shunt (Pentose Pathway)

Question 1

What is the MAIN GOAL of the HMP Shunt (Pentose Pathway)?

Answer 1

Produce NADPH

Question 2

What is NADPH required for?

Answer 2

1) Glutathione reduction
2) Fatty Acid synthesis
3) Cholesterol synthesis

Question 3

What is Glutathione required for?

Answer 3

Free radical detoxification

Question 4

Free radical detoxification requires:

Answer 4

Reduced Glutathione

Question 5

HMP Shunt (Pentose Pathway) initially starts with which reactant?

Answer 5

Glucose-6-Phosphate

Question 6

What is the very first conversion in the HMP Shunt (Pentose Pathway)?

Answer 6

Glucose-6-Phosphate is converted to 6-Phosphogluconolactone

Question 7

Which enzyme converts Glucose-6-Phosphate to 6-Phosphogluconolactone?

Answer 7

Glucose-6-Phosphate Dehydrogenase (G6PD)!!!!!!

Question 8

Glucose-6-Phosphate Dehydrogenase (G6PD) requires:

Answer 8

NADP+

Question 9

Glucose-6-Phosphate Dehydrogenase (G6PD) will take NADP+ and convert it to:

Answer 9

NADPH

Question 10

Where in the cell does the HMP Shunt (Pentose Pathway) occur?

Answer 10

In the cytoplasm

Question 11

In which organs does the HMP Shunt (Pentose Pathway) occur?

Answer 11

1) Liver
2) Mammary glands
3) Adrenal cortex